Search for dissertations about: "Familial melanoma"

Showing result 1 - 5 of 18 swedish dissertations containing the words Familial melanoma.

2. 1. Genetic characterization of malignant melanoma and breast cancer

   Author : Göran B Jönsson; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; microarray; inherited breast cancer; Melanoma; linkage analysis; cancer; Cytologi; cancerology; onkologi;

   Abstract : Malignant melanoma and breast cancer are common malignant diseases characterized by considerable heterogeneity with respect to genetics, histopathology, biology and clinical course. In breast cancer, two major susceptibility genes have been identified, BRCA1 and BRCA2, which account for a significant proportion of high-risk breast cancer families. READ MORE

4. 2. Cancer risks and prognosis in familial melanoma kindreds

   Author : Hildur Björg Helgadóttir; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malignant melanoma of the skin is one of the most rapidly increasing cancers in many western countries, including Sweden. This incidence rise is mainly attributed to sun-seeking habits with increased intermittent UVR exposure, a major risk factor for melanoma. READ MORE

5. 3. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

   Author : Susanne Magnusson; Bröstcancer-genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancer; hereditary factors; breast cancer; survival; hereditary breast and ovarian cancer; hereditary non-polyposis colorectal cancer; familial malignant melanoma; BRCA1; BRCA2; mismatch repair; CDKN2A; familial risk; multiple childhood tumors; Li-Fraumeni syndrome; TP53; adrenocortical carcinoma; choroid plexus tumors; rhabdomyosarcoma;

   Abstract : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. READ MORE

6. 4. Uveal melanoma : epidemiological and clinical aspects

   Author : Louise Bergman; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Melanoma; uveal; choroidal; epidemiology; population-based registry; incidence; survival; familial; ruthenium brachytherapy;

   Abstract : A major purpose with this thesis was to assess the incidence and mortality rates of uveal melanoma in Sweden during the period 1960 to 1998, using population-based registry data. In total, 2,995 patients (1,541 males and 1,454 females) were diagnosed with uveal melanoma. READ MORE

7. 5. Germline CDKN2A/ARF alterations in human melanoma

   Author : Jamileh Hashemi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Familial melanoma; germline mutation; CDKN2A; p16; p14ARF; cell cycle;

   Abstract : Approximately 10% of cases of human cutaneous malignant melanoma (CMM) have been estimated to occur in individuals with a familial predisposition, frequently in association with dysplastic nevus syndrome (DNS). The genetics of familial melanoma is complex and heterogeneous. To date only two melanoma predisposing genes have been identified. READ MORE