Search for dissertations about: "Farmaceutisk kemi"

Showing result 1 - 5 of 132 swedish dissertations containing the words Farmaceutisk kemi.

  1. 1. Lipid-based liquid crystals as drug delivery vehicles for antimicrobial peptides

    University dissertation from ; Chalmers tekniska högskola; Gothenburg

    Author : Lukas Boge; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hexosome; antimicrobial peptide; cubosome; proteolysis; AMP; liquid crystalline nanoparticles; glycerol monooleate; Liquid crystals;

    Abstract : The development of antimicrobial resistance is a great challenge within the health sector around the world. The demand for new efficient treatments is alarming in order to treat various bacterial infections in the near future. Antimicrobial peptides (AMPs) are a group of novel antibiotics that have gain more and more attraction the past decade. READ MORE

  2. 2. Drugs and polymers in dissolving solid dispersions NMR imaging and spectroscopy

    University dissertation from Stockholm : KTH

    Author : Carina Dahlberg; KTH.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURAL SCIENCES Chemistry Physical chemistry; NATURVETENSKAP Kemi Fysikalisk kemi; NATURAL SCIENCES Chemistry Physical chemistry Surface and colloid chemistry; NATURVETENSKAP Kemi Fysikalisk kemi Yt- och kolloidkemi; PHARMACY; FARMACI;

    Abstract : The number of poorly water-soluble drug substances in the pharmaceutical pipeline is increasing, and thereby also the need to design effective drug delivery systems providing high bioavailability. One favourable formulation approach is preparation of solid dispersions, where dispersing a poorly water-soluble drug in a water-soluble polymer matrix improves the dissolution behaviour and the bioavailability of the drug. READ MORE

  3. 3. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Targeting Different Genotypes and Drug-Resistant Variants

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Karin Belfrage; Uppsala universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitors; structure-activity relationship; 2 1H -pyrazinone; quinazoline; resistance; Pd catalysis; Medicinal Chemistry; Läkemedelskemi; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Since the first approved hepatitis C virus (HCV) NS3 protease inhibitors in 2011, numerous direct acting antivirals (DAAs) have reached late stages of clinical trials. Today, several combination therapies, based on different DAAs, with or without the need of pegylated interferon-α injection, are available for chronic HCV infections. READ MORE

  4. 4. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions PET Tracer Development Targeting the Vesicular Acetylcholine Transporter

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Roslin; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Carbonylation; palladium; carbon-11; radiochemistry; positron emission tomography; vesicular acetylcholine transporter; vesamicol; alkyl halide; oxidative carbonylation; acylamidine; oxadiazole; heterocycle; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. READ MORE

  5. 5. Lipid-based liquid crystals as drug delivery vehicles for antimicrobial peptides

    University dissertation from ; Chalmers tekniska högskola; Gothenburg

    Author : Lukas Boge; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; infection; phase behavior; antimicrobial effect; Liquid crystals; hexosome; antimicrobial resistance; AMP; antimicrobial peptide; pulmonary delivery; topical delivery; glycerol monooleate; bacterial membrane; cubosome; liquid crystalline nanoparticles; membrane interaction; proteolysis;

    Abstract : The development of antimicrobial resistance is a great challenge within health sectors worldwide. Thus, demand for new, efficient treatments is urgent in order to treat various bacterial infections. Antimicrobial peptides (AMPs) are a group of antibiotics that have gained more and more attraction in the past decade. READ MORE