Search for dissertations about: "Farmakologi"

Showing result 1 - 5 of 841 swedish dissertations containing the word Farmakologi.

  2. 1. Development and Evaluation of Nonparametric Mixed Effects Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Paul Baverel; Mats Karlsson; Radojka Savic; Nils Hoem; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonparametric; model; pharmacometrics; pharmacokinetics; pharmacodynamic; imprecision; covariate analysis; parameter distribution; SOCIAL SCIENCES Statistics; computer and systems science; SAMHÄLLSVETENSKAP Statistik; data- och systemvetenskap; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Biopharmaceutics; Biofarmaci; Clinical Pharmacology; Klinisk farmakologi; Computer Systems; Datorteknik; Farmakologi; Pharmacology; Statistics; Statistik;

    Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data.The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE

  4. 2. Spontaneous reporting of adverse drug reactions Possibilities and limitations

    University dissertation from Umeå : Farmakologi och klinisk neurovetenskap

    Author : Martin Bäckström; Tom Mjörndal; Rune Dahlqvist; Folke Sjökvist; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; adverse drug reactions; spontaneous reporting; metamizole; general practitioners; hospital physicians; under-reporting; economical inducement; nurses.; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; Clinical Pharmacology; klinisk farmakologi;

    Abstract : Adverse drug reactions (ADRs) constitute a major problem in society and in drug therapy. They are a common cause of short-term hospitalization, prolonged hospitalization and death. Spontaneous reporting of ADRs remains one the most effective methods for detecting new and serious drug reactions. READ MORE

  5. 3. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?

    University dissertation from Umeå : Farmakologi och klinisk neurovetenskap

    Author : Sandra Holt; Christopher J Fowler; Anders Bucht; Gunnar Tiger; Ruth A Ross; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; FAAH; anandamide; endocannabinoid; pH; inflammation; NSAID; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. READ MORE

  6. 4. Pharmacology of Palmitoylethanolamide and Related Compounds

    University dissertation from Umeå : Farmakologi och klinisk neurovetenskap

    Author : Kent-Olov Jonsson; Christopher J Fowler; Gunnar Tiger; Andrew SC Rice; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; anandamide; cannabinoid; FAAH; palmitoylethanolamide; palmitoylisopropylamide; inflammation; mast cells; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Anandamide (AEA) is an endogenous fatty acid which activates the same cannabinoid receptors as ∆9-tetrahydrocannabinol, the psychoactive substance in marijuana. In vivo, anandamide exerts a number of actions including effects upon pain and inflammation. READ MORE

  7. 5. Transcription Factor AP-2 in Relation to Serotonergic Functions in the Central Nervous System

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mattias Damberg; Elias Eriksson; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CNS; serotonin; transcription factors; AP-2; personality; antidepressants; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Eukaryotic gene transcription plays a regulatory role in mammalian developmental processes. It has been shown that transcriptional control is an important mechanism for specification of neurotransmitter phenotypes. READ MORE