Search for dissertations about: "Farmakologi"

Showing result 21 - 25 of 520 swedish dissertations containing the word Farmakologi.

2. 21. Endocannabinoids and N-acylethanolamines in translational pain research : from monoacylglycerol lipase to muscle pain

   Author : Nazdar Ghafouri; Christopher J Fowler; Andrew SC Rice; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Monoacylglycerol lipase; endocannabinoid; palmitoylethanolamide; N-acylethanolamines; microdialysis; chronic widespread pain; muscle pain; trapezius;

   Abstract : In the early nineties cannabinoid receptors, the main target for Δ9-tetrahydrocannabinol (THC), the psychoactive component of marijuana were identified. Shortly after their endogenous ligands, N-arachidonoylethanolamine (anandamide, AEA) and 2-diacylglycerol (2-AG) were characterized. READ MORE

4. 22. Endocannabinoid metabolism : the impact of inflammatory factors and pharmacological inhibitors

   Author : Jessica Karlsson; Christopher Fowler; Stig Jacobsson; Jürg Gertsch; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

   Abstract : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. READ MORE

5. 23. Mammalian brain acetylcholinesterase : a study of its solubilization, purification, molecular state and interactions with cholinergic ligands including an endogenous modulator

   Author : Bertil Niklasson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity chromatography; caudate nucleus; acetylcholinesterase; tetracaine; décaméthonium; d-tubocurarine; edrophonium; fluoride ion; hysteric properties; endogenous ligands to AChE;

   Abstract : Membrane bound AChE from calf brain caudate nucleus was solubilized by use of ion-free media in presence of 10~ M EDTA and 10“5M tetracaine. The irreversible release of AChE was more effectively inhibited by divalent ions compared to monovalent ions added to the medium. READ MORE

6. 24. Amine oxidases in dental pulp : a study with special regard to a semicarbazide-sensitive amine oxidase with catalytic potency towards serotonin

   Author : Astrid Norqvist-Sjöberg; Lars Oreland; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The amine oxidizing capacity of piglet dental pulp tissue has been investigated. At least six separate enzyme activities could be distinguished:- a soluble semicarbazide-sensitive (SSAO) activity towards benzylamine, most likely to be derived from the content of blood plasma within the pulp tissue;- a soluble pulp tissue SSAO activity with most properties in common with the plasma enzyme, however with great efficiency not only regarding benzylamine but also tryptamine;- a tissue bound SSAO activity with activity towards benzylamine, tryptamine, tyramine and ß-phenylethylamine;- a tissue bound semicarbazide-sensitive activity towards serotonin (SSA0-5HT) (a combination of properties never reported before);- a mitochondrially bound and clorgyline-sensitive monoamine oxidase-A (MAO-A) activity with activity towards serotonin;- a mitochondrially bound and deprenyl-sensitive MAO-B activity with activity towards e. READ MORE

7. 25. In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells

   Author : Dina Popova; Jacobsson Stig O.P.; Anna Forsby; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurotoxicity; Neuronal cell culture; P19 cells; SH-SY5Y cells; βIII-tubulin; Methylmercury; Okadaic acid; Acrylamide; MDMA; Piperazine-derived designer drugs.;

   Abstract : Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. READ MORE