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Showing result 1 - 5 of 199 swedish dissertations matching the above criteria.

2. 1. Endocannabinoid metabolism : the impact of inflammatory factors and pharmacological inhibitors

   Author : Jessica Karlsson; Christopher Fowler; Stig Jacobsson; Jürg Gertsch; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

   Abstract : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. READ MORE

4. 2. Sources of Arachidonic Acid in Platelets, Bone, Marrow and Gastrointestinal Tract

   Author : Li Zhou; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phospholipids; Megakaryocyte; Lysophosphatidylcholine; Lipoproteins; Linoleic acid; Intralipid; Interconversion; Gastrointestinal tract; Plasma free fatty acids; Fasting; Dietary fatty acids; Desaturase; Cholesterol; Chylomicron remnant; Chylomicron; Arachidonic acid; Bone marrow; Platelets; Protein S; Prothrombin; Triglycerides.; Biochemistry; Metabolism; Biokemi; metabolism;

   Abstract : This study investigates pathways by which the eicosanoid precursor pools in the platelets, bone marrow and the gastrointestinal (GI) mucosa are acquired and regulated, and in this context some aspects on the interaction between triglyceride (TG)-rich lipoproteins and platelets. 1. READ MORE

5. 3. Regulation of Elovl and fatty acid metabolism

   Author : Annelie Brolinson; Anders Jacobsson; Jaap Keijer; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fatty acid metabolism; fatty acid elongation; Physiology; Fysiologi; Physiology; fysiologi;

   Abstract : Fatty acids are important regulators in the control of mammalian energy homeostasis. They are ingested in the diet but a significant amount are also endogenously produced by de novo lipogenesis. READ MORE

6. 4. Dietary Fatty Acids and Inflammation : Observational and Interventional Studies

   Author : Helena Bjermo; Ulf Risérus; Tommy Cederholm; Parveen Yaqoob; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dietary fat; Fatty acids; Serum fatty acid composition; Linoleic acid; Stearoyl coenzymeA desaturase; SCD-1; Inflammation; C-reactive protein; Oxidative stress; Lipid peroxidation; Isoprostanes; Prostaglandins; Obesity; Epidemiology; Dietary intervention; Metabolic syndrome; Nutrition; Näringslära; Epidemiology; Epidemiologi; Public health science; Folkhälsovetenskap; Immunology; Immunologi; Diabetology; Diabetologi; Cardiology; Kardiologi; Medical Science; Medicinsk vetenskap;

   Abstract : Dietary fat quality influences the risk of type 2 diabetes and cardiovascular disease. A low-grade inflammation is suggested to contribute to the disease development, often accompanied by obesity. Whereas n-3 polyunsaturated fatty acids (PUFA) have been considered anti-inflammatory, n-6 PUFA have been proposed to act pro-inflammatory. READ MORE

7. 5. Development of sensitive cellular assay systems and their application to the identification of "orphan" seven-transmembrane receptors

   Author : Knut Kotarsky; Slemhinnans immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biokemi; Metabolism; Biochemistry; metabolism; leukotrieneB4; thiazolidinedione; 9-HODE; fatty acid; luciferase; GFP; reporter gene; preclinical assay; receptor; GPCR;

   Abstract : Seven-transmembrane, G-protein coupled receptors play a central role in physiology since they facilitate cell communication in multicellular organisms by recognition of a broad range of ligands. They also represent important drug targets. READ MORE