Search for dissertations about: "Fc"

Showing result 21 - 25 of 171 swedish dissertations containing the word Fc.

  2. 21. Rational and Combinatorial Engineering of Affinity Proteins Towards Therapeutical Applications

    Author : Johan Seijsing; Torbjörn Gräslund; Uhlén Mathias; Inger Sandlie; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neonatal Fc receptor; FcRn; affibody molecule; immunoglobulin G IgG ; serum albumin SA ; albumin binding domain ABD ; half-life extension; blocking; autoimmune disease; pH-dependence; GAD67; GAD-1; gene therapy; Parkinson’s disease; zinc finger based artificial transcription factor; Biotechnology; Bioteknologi;

    Abstract : Protein engineering has had an immense impact on the development of biological drugs, including replacement therapies with engineered versions of insulin or factor VIII to treat diabetes or bleeding disorders, and monoclonal antibodies to treat cancer and various other malignancies. Now, with the next generation of treatment modalities coming up, including monoclonal reagents based on alternative scaffolds, gene and cell therapies, the importance of protein engineering to tailor-make these treatments is likely to increase further. READ MORE

  4. 22. Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies

    Author : Linda Sandin; Thomas Tötterman; Mangsbo Sara; Fredrik Eriksson; Loskog Angelica; Ola Winqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ checkpoint blockade; antibody-mediated tumor immunotherapy; CTLA-4; CD40; monoclonal antibodies; experimental animal model; Fc gamma receptor; Medical Science; Medicinsk vetenskap;

    Abstract : Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. READ MORE

  5. 23. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

    Author : Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
    Keywords : Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

    Abstract : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. READ MORE

  6. 24. Characterisation of epitope-specific B cells and the role of IgG Fc sialylation in murine arthritis models

    Author : Alexander Krämer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autoimmune diseases are a major burden for society and economy. One of the most common autoimmune diseases is rheumatoid arthritis (RA) characterized by joint inflammation, swelling and pain. If left untreated, it ultimately leads to disability. READ MORE

  7. 25. B cells in Autoimmunity : Studies of Complement Receptor 1 & 2 and FcγRIIb in Autoimmune Arthritis

    Author : Kajsa Prokopec; Sandra Kleinau; Anna Erdei; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; complement receptors; fc gamma receptor IIb; autoimmune arthritis; rheumatoid arthritis; Immunology; Immunologi;

    Abstract : B cells are normally regulated to prevent activation against self-proteins through tolerance mechanisms.  However, occasionally there is a break in tolerance and B cells can become self-reactive, which might lead to the development of autoimmune disease. READ MORE