Search for dissertations about: "Fetal antigen 1"

Showing result 1 - 5 of 12 swedish dissertations containing the words Fetal antigen 1.

2. 1. Protein and mRNA Studies of Rat FA1/Pref-1/dlk

   Author : Gabriella Persdotter Hedlund; Jann Hau; Carina Carlsson; Torgny Stigbrand; Uppsala universitet; []
   Keywords : Laboratory animals; Preadipocyte factor 1; delta like protein; Fetal antigen 1; Goto-Kakizaki; Zucker; adipokines; adipose tissue; diabetes; obesity; Försöksdjursvetenskap;

   Abstract : The timing of cell differentiation is important for development and renewal of well functioning organs and tissues. One protein involved in this process is Preadipocyte factor 1 (Pref-1). Most likely, the role of this protein is to maintain cells in an undifferentiated state. READ MORE

4. 2. Fetal and neonatal alloimmune thrombocytopenia : immunological mechanisms and clinical consequences

   Author : Erle Refsum; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition that may occur in connection with pregnancy, when maternal antibodies directed against paternally inherited platelet antigens cross the placenta and mediate thrombocytopenia in the fetus and neonate. FNAIT puts the fetus at risk of severe bleedings, with an intracranial hemorrhage being the most feared outcome. READ MORE

5. 3. Experimental studies of human fetal liver cells : in regard to in utero hematopoietic stem cell transplantation

   Author : Bim Lindton; Karolinska Institutet; Karolinska Institutet; []
   Keywords : In utero transplantation; fetal liver cells; mixed lymphocyte culture; CD3; CD56; HLA class II; parvovirus B 19 capsids; corticosteroids; cytotoxic drugs; colony formation.;

   Abstract : Successful in utero hematopoietic stem cell transplantation represents a potential step forward in the management of patients with severe inherited hematological, metabolic and immunological disorders. Animal data from a number of species have demonstrated evidence of engraftment, but to date the only effective in utero transplantations (IUTx) in humans have been performed in fetuses with severe immunodeficiencies, suggesting that the fetal immune system play a vital role in the success or failure of in utero transplantation. READ MORE

6. 4. Xenograft Rejection : A Study of Cytokine mRNA Expression in Experimental Models

   Author : Henrik Krook; Anthony Dorling; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Type 1 diabetes; Parkinson’s disease; xenotransplantation; islets; neural tissue; heart; mRNA; cytokines; rejection.; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

   Abstract : Acute cellular xenograft rejection of ICCs triggered mRNA expression of proinflammatory cytokines (IL-1b and TNF-a), Th1 associated cytokines (IL-12p40, IL-2 and IFN-g) and Th2 associated cytokines (IL-4 and IL-10). The peak values and the kinetics of the mRNA expression indicated that acute cellular xenograft rejection is enhanced by the proinflammatory response and mediated by the Th1 associated response, whereas the function of the Th2 associated response most likely is to counteract the Th1 associated cytokines and thereby inhibit bystander damage by the delayed type hypersensitivity like rejection process. READ MORE

7. 5. Immunoglobulin isotype switching in health and disease

   Author : Berivan Baskin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Immunoglobulin isotype switching is the process where the Cmy region, initially located downstream of the VDJ region is replaced by another constant region gene. Class switch recombination takes place between switch (S) regions, composed of tandem repeats of short unit sequences, located 5 of each CH gene, except for Cdelta. READ MORE