Search for dissertations about: "Filamin"

Showing result 1 - 5 of 10 swedish dissertations containing the word Filamin.

  2. 1. Filamin A in Cardiovascular Remodeling

    Author : Sashidar Bandaru; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Filamin A; Cardiovascular remodelling;

    Abstract : Filamin A (FLNA) is a large actin-binding cytoskeletal protein that stabilizes actin networks and integrates them with cell membranes. FLNA is therefore important for cell motility and organ development. READ MORE

  4. 2. Structural Study of the WH2 Family and Filamin: Implications for Actin Cytoskeleton Regulation

    Author : Adeleke H. Aguda; Robert Robinson; Lars Rask; Lars Backman; Uppsala universitet; []
    Keywords : Biochemistry; Actin; Thymosin; Ciboulot; N-WASP; Filamin; Calponin homology domain; WH2; Protein Crystallography; Biokemi;

    Abstract : Cellular processes like motility, chemotaxis, phagocytosis and morphogenesis are dependent on the dynamic regulation of the actin cytoskeleton. This cytoskeleton system is tightly controlled by a number of diverse actin-binding proteins (ABPs) by various mechanisms described as nucleation, polymerization, capping, severing, depolymerization and sequestration. READ MORE

  5. 3. Mechanism of F-actin crosslinking by filamin A and the anti-inflammatory functions of plasma gelsolin in bodily fluids

    Author : Teresia Magnuson Osborn; Göteborgs universitet; []
    Keywords : Cytoskeleton; Crosslinking; F-actin; Filamin; Gelsolin; Inflammation; Plasma; Platelet-activating factor; Lysophosphatidic acid; Rheumatoid arthritis;

    Abstract : Gelsolin (GSN) and filamin A (FLNa) are two actin-binding proteins discovered in our laboratory over 30 years ago. GSN is a calcium-activated actin severing and barbed end capping protein that is expressed as both intracellular and extracellular (plasma gelsolin, pGSN) isoforms. READ MORE

  6. 4. Role of angiogenesis in cancer invasion and metastasis

    Author : Pegah Rouhi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer metastasis is a complex process that involves an elaborate interplay between malignant cells and various host cellular and molecular components. The metastatic cascade consists of several discrete but non-separable steps, including: 1) malignant transformation of cells; 2) intravasation and dissemination of tumor cells into the circulation or lymphatic system; 3) transport of malignant cells to distal organs and tissues; 4) adherence of tumor cells to distal sites; 5) formation of the initial metastatic niches, and 6) angiogenesis-dependent re-growth of metastatic foci to clinically detectable tumors. READ MORE

  7. 5. Variation in length of proteins by repeats and disorder regions

    Author : Rauan Sagit; Arne Elofsson; Andrey Kajava; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein length; repeats; domain repeats; protein evolution; duplication; tandem duplication; intrinsic disorder; intrinsically disordered; variation in length; insertion; deletion; recombination; expansion; contraction; Biochemistry; biokemi;

    Abstract : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. READ MORE