Search for dissertations about: "Flow Cytometry"

Showing result 16 - 20 of 389 swedish dissertations containing the words Flow Cytometry.

  2. 16. Investigations of Hematopoietic Stem Cells and Their Age-Associated Alterations

    Author : Alexandra Rundberg Nilsson; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; Aging; Serial transplantation; Self-renewal; Flow cytometry; Gene expression;

    Abstract : The hematopoietic stem cell (HSC) has and continues to be extensively investigated, and represents by far the most studied somatic stem cell. Development of various experimental technologies, including fluorescence activated cell sorting (FACS), have been crucial for research advancements within the hematopoietic field. READ MORE

  4. 17. Heterogeneity of leukemic cells with regard to daunorubicin accumulation and efflux : potential role in drug resistance

    Author : Eva Knaust; Linköpings universitet; []
    Keywords : Drug resi stance. acute myeloid leukemia; flow cytometry; gene expression; transport kinetics; apoptosis; MEDICINE; MEDICIN;

    Abstract : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myelocytic leukemia (AML) and other malignancies. Drug resistance is multifactorial; the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (PPG), a transmembrane transport protein with a pump function, encoded by the mdr 1 gene. READ MORE

  5. 18. High Content Analysis of Proteins and Protein Interactions by Proximity Ligation

    Author : Karl-Johan Leuchowius; Ola Söderberg; Ulf Landegren; Paul Goldsmith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ; proximity ligation; flow cytometry; high content screening; rolling circle amplification; in situ PLA; single-cell; single-molecule; protein interactions; drug screening; post-translational modifications; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Abstract : Fundamental to all biological processes is the interplay between biomolecules such as proteins and nucleic acids. Studies of interactions should therefore be more informative than mere detection of expressed proteins. Preferably, such studies should be performed in material that is as biologically and clinically relevant as possible, i.e. READ MORE

  6. 19. Applications of in situ proximity ligation assays for cancer research and diagnostics

    Author : Liza Löf; Masood Kamali-Moghaddam; Ulf Landegren; J.Paul Robinson; Uppsala universitet; []
    Keywords : Cancer; Diagnostics; Research; Prognostics; Method development; Flow cytometry; Drug delivery; Molekylär medicin; Molecular Medicine;

    Abstract : In the field of cancer research and diagnostics it is crucial to have reliable methods for detecting molecules involved in the disease. New and better methods for diagnostics, prognostics and drug delivery therefore remain a permanent aim. READ MORE

  7. 20. Congenital Dyserythropoietic Anemia type III (CDA III) : diagnostics, genetics and morbidity

    Author : Maria Liljeholm; Anders Wahlin; Richard Rosenquist Brandell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; congenital dyserythropoietic anemia; KIF23; hereditary hemochromatosis; iron overload; flow cytometry;

    Abstract : The Congenital Dyserythropoietic Anemias (CDA) are rare hereditary hemolytic disorders with large bi- to multi-nucleated erythroblasts in the bone marrow. Hemolysis is negative in a direct antiglobulin test (DAT). Based on morphology and clinical picture, three major forms of CDAs, type I, II, and III have been defined. READ MORE