Search for dissertations about: "Fluorescence in situ hybridization"
Showing result 21 - 25 of 56 swedish dissertations containing the words Fluorescence in situ hybridization.
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21. Arrayed identification of DNA signatures
Abstract : In this thesis techniques are presented that aim to determine individual DNA signatures by controlled synthesis of nucleic acid multimers. Allele-specific extension reactions with an improved specificity were applied for several genomic purposes. Since DNA polymerases extend some mismatched 3’-end primers, an improved specificity is a concern. READ MORE
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22. Molecular cytogenetic investigations of chromosomal abnormalities in prostate and urinary bladder cancers
Abstract : Tumorigenesis is suggested to be caused by base pair mutations and chromosomal abnormalities leading to inactivation of tumor suppressor genes an activation of oncogenes. However, still it is not clear for the vast majority of these changes how they contribute to the tumorigenesis of the prostate and bladder cancers. READ MORE
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23. Interphase cytogenetics and cytokine therapy in myelodysplastic syndromes and acute myeloid leukemia
Abstract : Myelodysplastic syndromes (MDS) comprise a group of clonal hematopoietic bone marrow cell disorders, characterized by a variable degree of anemia, granulocytopenia and/or thrombocytopenia and with a substantial risk of transformation to acute myeloid leukemia (MDS-AML). In the present thesis a method based on fluorescence in situ hybridization (FISH) was developed which allows cytogenetic studies on morphological identified peripheral blood and bone marrow cells (MGG/FISH). READ MORE
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24. Analysis of chromosomal rearrangements and gene copy number changes in breast cancer cells
Abstract : Genome changes in terms of numerical chromosomal aberrations and structural rearrangements, including deletions, amplifications and translocations, gradually accumulate in the genome during tumor development. These genomic changes are likely to play an important role in the process of tumor progression. READ MORE
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25. A microcell hybrid based 'elimination test' in the search for malignancy related genes
Abstract : This thesis is focused on the elimination test developed by us (Imreh et al, 1994). The elimination test was designed as a functional test for malignancy related gene identification. Its task is to follow the cytogenetic and molecular alterations on single normal chromosomes transferred into tumor cells. READ MORE