Search for dissertations about: "Fluorescent base analogue"
Found 5 swedish dissertations containing the words Fluorescent base analogue.
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1. DNA and RNA base analogue FRET - from fluorophore design to biochemical applications
Abstract : This thesis focuses on the development and use of fluorescent base analogues (FBAs). They are important tools in research concerning nucleic acids structure, dynamics and interactions. READ MORE
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2. Expanding the alphabet of fluorescent nucleic acid base analogues: Characterization of new members
Abstract : Fluorescence has proven to be a powerful tool for studying structure, dynamics and interactions of biomolecules such as proteins, RNA and DNA. However, since the natural DNA/RNA nucleobases are virtually non-fluorescent, there is a need for developing fluorescent nucleic acid markers. READ MORE
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3. Fluorescent Nucleobase Analogues and their use for Investigating DNA Interactions
Abstract : Ever since unravelling the structure of DNA, an expanding research field has emerged with ongoing efforts dedicated to increase our understanding of the molecule of life. Since the natural nucleobases are virtually non-emissive, it has been a challenge for decades to ‘light up’ DNA/RNA in order to investigate their properties utilizing fluorescence techniques. READ MORE
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4. Recognition and Visualization of Nucleic Acids
Abstract : The work presented in this Thesis focuses on the interaction between nucleic acids and small molecules, as well as binding or incorporation of reporter chromophores into nucleic acids. The results could help in studying and understanding processes that are fundamental to describe mechanisms behind a genetic disorder. READ MORE
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5. A biophysical study of nucleic acid interactions with analogues and drugs
Abstract : work presented in this thesis concerns studies on the physicochemical nature of interactions between nucleic acids and small ligands. The outcome of such studies can yield insights at a molecular level into the physiological mechanisms of action of biologically active nucleic-acid binding molecules. READ MORE
