Search for dissertations about: "Fluorouracil"
Showing result 1 - 5 of 46 swedish dissertations containing the word Fluorouracil.
-
1. Intraperitoneal 5-Fluorouracil treatment of cancer - clinical and experimental studies
Abstract : Background:Pancreas cancer is a most aggressive malignancy. More than 80% of patients diagnosed with pancreas cancer, exhibit such advanced disease, that curative surgery is impossible. Systemic chemotherapy prolongs survival to 5-9 months. READ MORE
-
2. Pathophysiology of 5-fluorouracil induced cardiotoxicity : a clinical and experimental study
Abstract : This thesis concerns the pathophysiology of 5-fluorouracil (5-FU) induced cardiotoxicity. The aim of the clinical studies was to determine whether hemorheological factors might explain 5-FU cardiotoxicity (I) and if the syndrome was associated with free radical (FR) generation and lipid peroxidation (II). READ MORE
-
3. Endothelial and cardiac effects of 5-fluorouracil. An experimental and clinical study
Abstract : The cytostatic drug 5-fluorouracil (5-FU) has been shown to affect both morphology and function of vascular endothelium. These effects could be part of the pathophysiology for 5-FU induced cardiotoxicity. The present thesis explores the mechanisms of this endothelial toxicity. READ MORE
-
4. Effects of 5-fluorouracil on oral barrier functions
Abstract : Many anticancer drugs, e.g. 5-fluorouracil (5-FU), may cause oral mucositis and ulcerations. These adverse reactions can be severe and debilitating to the patient, and adjustment of the cancer treatment may be necessary. READ MORE
-
5. Studies of Intracellular Transport and Anticancer Drug Action by Functional Genomics in Yeast
Abstract : This thesis describes the use of functional genomics screens in yeast to study anticancer drug action and intracellular transport. The yeast Saccharomyces cerevisiae provides a particularly useful model system for global drug screens, due to the availability of knockout mutants for all yeast genes. READ MORE