Search for dissertations about: "Follicular B cell"

Showing result 21 - 25 of 59 swedish dissertations containing the words Follicular B cell.

  2. 21. Exploring lymphocyte subsets, autoantibodies and the effect of B cell targeted therapies in rheumatic diseases

    Author : Natalie Sippl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nowadays, around 100 different diseases sort under the umbrella of rheumatic diseases(1). They involve different mechanisms and symptoms engaging joints, tendons, ligaments, bones, muscles but also vital organs like the kidneys nervous system and circulation. READ MORE

  4. 22. Characterisation of molecular alterations in diffuse large b-cell lymphoma with respect to transformation, progression and prognostic markers

    Author : Anna Kwiecińska; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma type, and comprises nearly 500 newly diagnosed cases in Sweden every year. DLBCL is a group of aggressive lymphomas that are extremely heterogeneous and differ in morphology, immunophenotype, molecular and clinical features as well as in response to therapy. READ MORE

  5. 23. Early Immunostimulatory Effects of IgE- and IgG Antibodies

    Author : Fredrik Hjelm; Birgitta Heyman; Sandra Kleinau; Robert Harris; Uppsala universitet; []
    Keywords : Immunology; Antibodies; Fc receptors; Antigen presentation; B cells; T cells; Immunologi;

    Abstract : Antibodies have the ability to influence their own production in a process called antibody feedback regulation. Depending on the type of antigen and the subclass of the antibody, the outcome of feedback regulation can be complete suppression or several hundred-fold enhancement of the antibody response. READ MORE

  6. 24. THE ROLE OF DENDRITIC CELLS AND TYPE I INTERFERON IN THE GENERATION AND FUNCTION OF T FOLLICULAR HELPER CELLS

    Author : Helena Cucak; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T follicular helper cells; Type I interferon; Dendritic cells;

    Abstract : Generation of long-lived plasma cells and memory B cells of high affinity takes place in germinal centers and depends on help from a specialized CD4+ T cell subset termed T follicular helper (Tfh) cells. These processes are crucial for long-term protection upon natural infection or in settings of vaccination, however they are also responsible for development of antibody-mediated autoimmune disease. READ MORE

  7. 25. The Role of IgM and Complement in Antibody Responses

    Author : Christian Rutemark; Birgitta Heyman; Claus Nielsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

    Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE