Search for dissertations about: "FoxO1"

Showing result 1 - 5 of 20 swedish dissertations containing the word FoxO1.

  2. 1. Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ

    Author : Emelie Wallerstedt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2-Diabetes; inflammation; obesity; IL-6; STAT3; PKCδ; FOXO1;

    Abstract : The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated the importance of PKCδ in 3T3-L1 adipocytes and mouse embryonic fibroblasts (MEFs) lacking protein kinase C-δ (PKCδ-/-) (Paper II). READ MORE

  4. 2. Protein expression and modifications in denervated atrophic and hypertrophic skeletal muscle

    Author : Kim Evertsson; Sven Tågerud; Håkan Westerblad; Linnéuniversitetet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeletal muscle; denervation; atrophy; hypertrophy; protein expression; protein phosphorylation; Akt; p38; MK2; Hsp25; Hsp70; FoxO1; MuRF1; autophagy; Lamp1; Lc3; Biomedical Sciences; Biomedicinsk vetenskap;

    Abstract : Skeletal muscle comprises about 45% of the total body weight. It is the largest tissue in the body, vital for maintaining posture, produce locomotion, breathing but also functions as a large reservoir of proteins. READ MORE

  5. 3. ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT

    Author : Eva Welinder; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. READ MORE

  6. 4. Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)

    Author : Meenu Rohini Rajan; Peter Strålfors; Mats Söderström; Olga Göransson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. READ MORE

  7. 5. Interleukin 15 throughout murine natural killer cell biology

    Author : Thuy Thanh Luu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are innate immune cells that mount responses against virally infected, transformed and allogeneic transplanted cells. Equipped with cytolytic molecules and death receptors, NK cells mediate cytotoxicity against cells expressing low levels of MHC class I (MHC-I) or high levels of stress-induced molecules. READ MORE