Search for dissertations about: "Fragment Based Lead Discovery"
Showing result 6 - 9 of 9 swedish dissertations containing the words Fragment Based Lead Discovery.
-
6. Discovery of Chemical Probes through Structure-based Virtual Screening of Vast Compound Databases
Abstract : Bioactive molecules have traditionally been discovered through labor-intensive screening methods in which individual compounds are tested against specific protein targets or cells to identify those that produce the desired biological effect. However, these approaches have significant limitations. READ MORE
-
7. Reducing Attrition via Improved Strategies for Pre-clinical Drug Discovery : SPR-biosensor Aided Interaction Studies
Abstract : The efficacy of a drug is tightly intertwined with its interaction mechanism with the drug target. The mechanism is dependent on the physicochemical and structural characteristics of both target and drug molecule.Drug discovery is plagued by a high attrition rate, whereas in the clinic, a major issue is drug resistance. READ MORE
-
8. The impact of GPCR structures on understanding receptor function and ligand binding
Abstract : G protein-coupled receptors (GPCRs) form the largest superfamily of eukaryotic membrane proteins and are responsible for the action of nearly 30% of all marketed drugs. For a long period, efforts to study these receptors were limited by the paucity of atomic-resolution structural information. READ MORE
-
9. Development and Application of Computational Models for Peptide-Protein Complexes
Abstract : Protein-protein interactions between a protein and a smaller protein fragment or a disordered segment of a protein are called peptide-protein interactions. Such interactions are commonplace in nature and vital for normal cell function in humans. READ MORE
