Search for dissertations about: "Francisella tularensis"

Showing result 1 - 5 of 26 swedish dissertations containing the words Francisella tularensis.

  1. 1. The oxidative stress response of Francisella tularensis

    Author : Marie Honn; Anders Sjöstedt; Helena Lindgren; Andres Melendez; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

    Abstract : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. READ MORE

  2. 2. Cutaneous resistance against Francisella tularensis

    Author : Stephan Stenmark; Mikael Rhen; Umeå universitet; []
    Keywords : tularemia; Francisella tularensis; skin; protection; cytokines; T-cells; B-cells; specific antibodies; Infectious Diseases; infektionssjukdomar;

    Abstract : Francisella tularensis, the causative agent of tularemia, is a potent pathogen in humans and other mammals. The ulceroglandular form of the disease is the most common expression in humans with a clinical picture characterized by a skin ulcer, enlarged regional lymph nodes and fever. READ MORE

  3. 3. Francisella tularensis: persistence, dissemination and source attribution : a theoretical and computational approach

    Author : Chinmay Kumar Dwibedi; Anders Johansson; Pär Larsson; Markus Antwerpen; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; genomics; evolution; microbial forensics; dispersal; persistence; mikrobiologi; Microbiology;

    Abstract : The bacterium Francisella tularensis causing tularemia in humans and other mammals displays little genetic diversity among genomes across temporal and spatial scales. F. tularensis infects humans with an extremely low infectious dose and causes natural seasonal tularemia outbreaks. READ MORE

  4. 4. Identification of new virulence factors in Francisella tularensis

    Author : Anna-Lena Forslund; Åke Forsberg; Elisabeth Carniel; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Francisella tularensis; regulation; virulence; Hfq; DsbA; type IV pili; membrane; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Francisella tularensis, the causative agent of tularemia, is a highly virulent bacterium with an infection dose of less than ten bacteria. The ability of a pathogen to cause infection relies on different virulence mechanisms, but in Francisella tularensis relatively few virulence factors are known. Two F. READ MORE

  5. 5. The genetic composition and diversity of Francisella tularensis

    Author : Pär Larsson; Anders Sjöstedt; Andrew K. Benson; Umeå universitet; []
    Keywords : Microbiology; tularemia; genotyping; evolution; microarray; genome sequencing; virulence; genome reduction; Mikrobiologi; Francisella tularensis; klinisk bakteriologi; Clinical Bacteriology;

    Abstract : Francisella tularensis is the causative agent of the debilitating, sometimes fatal zoonotic disease tularemia. To date, little information has been available on the genetic makeup of this pathogen, its evolution, and the genetic differences which characterize subspecific lineages. These are the main areas addressed in this thesis. READ MORE