Search for dissertations about: "Fredrik Almqvist"

Showing result 1 - 5 of 24 swedish dissertations containing the words Fredrik Almqvist.

  1. 1. Synthesis of Optically Active Bicyclo[2.2.2]octane Derivatives - A Study Towards Novel Taxol Mimics and Development of New Chiral Ligands for Asymmetric Catalysis

    University dissertation from Organic Chemistry, Lund University

    Author : Fredrik Almqvist; [1996]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lewis acids; Asymmetric reduction; Asymmetric catalysis; Bidentate ligands; Enantioenriched; Optically active; Spiro; Taxol mimic; Bicyclo[2.2.2]octane derivatives; Ti IV complexes; Organic chemistry; Organisk kemi;

    Abstract : This thesis is a summary of six papers which concern synthesis of optically active bicyclo[2.2.2]octane derivatives. The derivatives prepared are important building blocks in a study towards a possible replacement of the diterpenoidic part of taxol, (baccatin III), so as to construct a taxol mimic. READ MORE

  2. 2. Reaction Between Grignard reagents and Heterocyclic N-oxides Synthesis of Substituted Pyridines, Piperidines and Piperazines

    University dissertation from Umeå : Umeå universitet

    Author : Hans Andersson; Fredrik Almqvist; Hans Adolfsson; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Grignard reagents; pyridine N-oxide; pyrazine N-oxide; dienal-oxime; pyridine; ortho- metalation; piperidine; piperazine; asymmetric; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes the development of new synthetic methodologies for preparation of bioactive interesting compounds, e.g. substituted pyridines, piperidines or piparazines. Thesecompounds are synthesized from commercially available, cheap and easily prepared reagents, videlicet the reaction between Grignard reagents and heterocyclic N-oxides. READ MORE

  3. 3. Multimodal Porphyrin-Based Conjugates Synthesis and characterization for applications as amyloid ligands, photodynamic therapy agents and chiroptical materials

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Katriann Arja; Peter Nilsson; Peter Konradsson; Fredrik Almqvist; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly effect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy called photodynamic therapy. READ MORE

  4. 4. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

    University dissertation from Umeå : Umeå universitet

    Author : Christoffer Bengtsson; Fredrik Almqvist; Paul Helquist; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

    Abstract : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. READ MORE

  5. 5. Pilicides and Curlicides Design, synthesis, and evaluation of novel antibacterial agents targeting bacterial virulence

    University dissertation from Umeå : Umeå universitet, Kemiska Institutionen

    Author : Erik Chorell; Fredrik Almqvist; Stephen Hanessian; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pilicide; curlicide; anti-virulence; chaperone usher pathway; antibacterial; pili; curli; Escherichia coli; biofilm inhibitor; 2-pyridone; peptidomimetic; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry Bioorganic chemistry; NATURVETENSKAP Kemi Organisk kemi Bioorganisk kemi; NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry; NATURVETENSKAP Kemi Organisk kemi Läkemedelskemi; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; MEDICINE Microbiology; immunology; infectious diseases Infectious diseases; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Infektionssjukdomar; Biorganic Chemistry; bioorganisk kemi; Infectious Diseases; infektionssjukdomar; datorlingvistik; computational linguistics; organisk kemi; Organic Chemistry;

    Abstract : New strategies are needed to counter the growing problem of bacterial resistance to antibiotics. One such strategy is to design compounds that target bacterial virulence, which could work separately or in concert with conventional bacteriostatic or bactericidal antibiotics. READ MORE