Search for dissertations about: "Free Fatty Acid Receptor 2"

Showing result 1 - 5 of 24 swedish dissertations containing the words Free Fatty Acid Receptor 2.

2. 1. Effects of Free Fatty Acids on Insulin and Glucagon Secretion : – with special emphasis on the role of Free fatty acid receptor 1

   Author : Hjalti Kristinsson; Peter Professor; Birgitte Holst; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FFAR1; GPR40; palmitate; lipotoxicity; islets of Langerhans; type 2 diabetes; obesity; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Prevalence of type 2 diabetes mellitus (T2DM) is still rising and even so in the juvenile population. Obesity is highly associated with increased risk for developing T2DM. READ MORE

4. 2. Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils

   Author : Simon Lind; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neutrophils; G protein coupled receptors; Free Fatty Acid Receptor 2; GPR43; Allosteric modulation; Transactivation; Cross-talk; Biased signalling; Functional selectivity;

   Abstract : The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl peptide receptors (FPRs) and the short free fatty acid receptors (FFARs) belong to the family of G protein coupled receptors (GPCR). READ MORE

5. 3. Common variants in genes regulating free fatty acid metabolism and risk of type 2 diabetes and cardiovascular disease

   Author : Martin Carlsson; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; free fatty acids; genetics; UCP1; beta3-adrenergic receptor; beta2-adrenergic receptor; type 2 diabetes mellitus; FABP2; stroke; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Abstract : Abstract The present study evaluated genetic and metabolic factors influencing the risk for type 2 diabetes and cardiovascular disease (CVD) with special reference to increased concentrations of free fatty acids (FFA) in 1174 Swedish diabetic and nondiabetic subjects. Common polymorphisms in the fatty acid binding protein 2 (FABP2), the B2-adrenergic receptor (B2-AR), the B3 -adrenergic receptor (B3-AR) and the uncoupling protein 1 (UCP-1) genes were related to anthropometric and metabolic variables. READ MORE

6. 4. The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion

   Author : Erik Flodgren; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; GPCR; Glucagon; GPR40; Insulin; Free fatty acid; Endokrinologi; sekretion; diabetologi;

   Abstract : Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. READ MORE

7. 5. Sources of Arachidonic Acid in Platelets, Bone, Marrow and Gastrointestinal Tract

   Author : Li Zhou; Lund Medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phospholipids; Megakaryocyte; Lysophosphatidylcholine; Lipoproteins; Linoleic acid; Intralipid; Interconversion; Gastrointestinal tract; Plasma free fatty acids; Fasting; Dietary fatty acids; Desaturase; Cholesterol; Chylomicron remnant; Chylomicron; Arachidonic acid; Bone marrow; Platelets; Protein S; Prothrombin; Triglycerides.; Biochemistry; Metabolism; Biokemi; metabolism;

   Abstract : This study investigates pathways by which the eicosanoid precursor pools in the platelets, bone marrow and the gastrointestinal (GI) mucosa are acquired and regulated, and in this context some aspects on the interaction between triglyceride (TG)-rich lipoproteins and platelets. 1. READ MORE