Search for dissertations about: "Fritiof Pontén"

Found 2 swedish dissertations containing the words Fritiof Pontén.

2. 1. Synthesis and Rearrangement of Epoxy Sugars

   Author : Fritiof Pontén; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; crown ether; silica; Intramoleculaf Diels-Alder reaction; radical allylation; allyl sulfone; sugar epoxide; allyl sulfide; ring-contraction; C-glycoside; a; IMDAF; b-unsaturated aldehyde;

   Abstract : Ring-Contraction of sugar-derived epoxy alcohols, functionalised in position 1 and 6, by treatment with lithium bromide and N, N, N', N'-tetramethylurea in refluxing toluene gave enantiomerically pure a,b-unsaturated aldehydes of furanosides. O-Glycosidic epoxy alcohols gave only one, easily purified, aldehyde in approximately 30-60% yield depending on the substitution pattern. READ MORE

4. 2. New alternatives to combat Listeria monocytogenes and Chlamydia trachomatis : Design, synthesis, and evaluation of substituted ring-fused 2-pyridones as anti-virulent agents

   Author : Martina Kulén; Fredrik Almqvist; Anna Linusson Jonsson; Fritiof Pontén; Morten B. Strøm; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; anti-virulence; Listeria monocytogenes; Chlamydia trachomatis; ring-fused 2-pyridone; organic synthesis; structure-based design; PrfA; drug design; structure-activity relationship;

   Abstract : Antibiotic resistance has become a global health burden with the number of resistant bacteria continuously increasing. Antibiotic drugs act by being either bactericidal (killing bacteria) or bacteriostatic (inhibiting growth of bacteria). However, these modes of action increase the selective pressure on the bacteria. READ MORE