Search for dissertations about: "FunCoup"

Showing result 1 - 5 of 7 swedish dissertations containing the word FunCoup.

  2. 1. Inference of functional association networks and gene orthology

    Author : Thomas Schmitt; Erik L. L. Sonnhammer; Søren Brunak; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; orthology; InParanoid; FunCoup; systems biology; biological networks; network inference; functional coupling; functional association; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

    Abstract : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. READ MORE

  4. 2. From networks to pathway analysis

    Author : Miguel Castresana Aguirre; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Biological mechanisms stem from complex intracellular interactions spanning across different levels of regulation. Mapping these interactions is fundamental for the understanding of all types of biological conditions, including complex diseases. Each experimental approach carries its own bias and noise. READ MORE

  5. 3. Global functional association network inference and crosstalk analysis for pathway annotation

    Author : Christoph Ogris; Erik Sonnhammer; Alfonso Valencia; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; biological networks; genome wide functional association networks; global gene association networks; gene networks; protein networks; functional association; functional coupling; network biology pathway analysis; pathway annotation; pathway enrichment; network-based enrichment; enrichment; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Cell functions are steered by complex interactions of gene products, like forming a temporary or stable complex, altering gene expression or catalyzing a reaction. Mapping these interactions is the key in understanding biological processes and therefore is the focus of numerous experiments and studies. READ MORE

  6. 4. Functional association networks for disease gene prediction

    Author : Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. READ MORE

  7. 5. Functional Inference from Orthology and Domain Architecture

    Author : Mateusz Kaduk; Erik Sonnhammer; Erich Bornberg-Bauer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Orthology; Functional coupling networks; Association networks; Hierarchical groups of orthologs; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Abstract : Proteins are the basic building blocks of all living organisms. They play a central role in determining the structure of living beings and are required for essential chemical reactions. One of the main challenges in bioinformatics is to characterize the function of all proteins. READ MORE