Search for dissertations about: "Functionally Selective Ligand"

Found 4 swedish dissertations containing the words Functionally Selective Ligand.

  1. 1. New Paradigms in GPCR Drug Discovery Structure Prediction and Design of Ligands with Tailored Properties

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mariama Jaiteh; Jens Carlsson; David E Gloriam; [2020]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Docking; Virtual Screening; Homology Modeling; Molecular Dynamics Simulation; Chemical Library; Functionally Selective Ligand; Polypharmacology; Dimerization; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. READ MORE

  2. 2. Ion channels in drug discovery : Focus on biological assays

    University dissertation from Stockholm : Karolinska Institutet, Department of Physiology and Pharmacology

    Author : Kim Dekermendjian; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

    Abstract : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. READ MORE

  3. 3. Molecular Imprinting Technology. Design and Recognition Properties of Antibody/Receptor Mimics

    University dissertation from Pure and Applied Biochemistry, Lund University

    Author : Olof Ramström; [1996]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Template Polymerisatio; Steroid; Receptor; Racemic Resolution; Polymer; Molecular Recognition; Molecular Imprinting; Enantiomeric Separation; de novo Design; Chromatography; Chiral Stationary Phase; Chiral Recognition; Biorecognition; Antibody; Biomimetic; Biochemistry; Metabolism; Biokemi; metabolism; Biotechnology; Bioteknik;

    Abstract : Molecular imprinting technology is derived from the concept of creating designed recognition sites in macromolecular matrices by means of template polymerisation. Molecularly imprinted polymers are able to mimic recognition in natural binding events, such as antibody-antigen and receptor-ligand interactions. READ MORE

  4. 4. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC)

    Author : Beata Kostyszyn; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. READ MORE