Search for dissertations about: "Funktionella Varianter"

Showing result 1 - 5 of 9 swedish dissertations containing the words Funktionella Varianter.

  1. 1. Dissecting the Genetic Basis of Systemic Lupus Erythematosus The Pursuit of Functional Variants

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Angélica María Delgado Vega; Ulf Gyllensten; Marta E. Alarcon-Riquelme; Jane Worthington; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Systemic Lupus Erythematosus; SLE; Genetic Mapping; Association Studies; Functional Variants; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Systemisk Lupus Erythematosus; SLE; Genetik; Genetisk Association; Funktionella Varianter; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Lupus Eritematoso Sistémico; LES; Estudios de Asociación Genética; Variantes Funcionales; TNFSF4; STAT4; IRF5; CD226; BLK; BANK1; Medical Genetics; Medicinsk genetik; Medical Science; Medicinsk vetenskap;

    Abstract : Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease that primarily affects women during the childbearing years. SLE is characterized by the production of autoantibodies against nucleic acids and their interacting proteins. READ MORE

  2. 2. MHC polymorphism and host-pathogen interactions: The case of Borrelia in its reservoir host, the bank vole Myodes glareolus

    University dissertation from Department of Biology, Lund University

    Author : Kristin Scherman; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Host-pathogen interaction; Negative frequency dependent selection; Myodes glareolus; Borrelia;

    Abstract : The major histocompatibility complex (MHC) class IIB genes exhibit extensive allelic polymorphism, most likely maintained by pathogen-mediated balancing selection (PMBS). PMBS may operate in the form of heterozygote advantage (HA), and/or through the interaction of pathogens and specific MHC alleles via fluctuating selection (FS) or negative frequency-dependent selection (NFDS). READ MORE

  3. 3. The impact of glucotoxicity on pancreatic β-cell function

    University dissertation from Diabetes Centre, Lund University

    Author : Sarheed Jabar Muhammed; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Abstract : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. READ MORE

  4. 4. On protein structure, function and modularity from an evolutionary perspective

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Robert Pilstål; Björn Wallner; Maria Sunnerhagen; Mauno Vihinen; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; structure; biology; intrinsical; disorder; protein; sequence; evolution; mutation; epistasis; function; allostery; dynamics; simulation; prediction; graph; network; bioinformatik; struktur; biologi; strukturbiologi; intrinsiellt; oordnad; protein; sekvens; evolution; mutation; epistasis; funktion; allosteri; dynamik; simulation; prediktion; graf; nätverk;

    Abstract : We are compounded entities, given life by a complex molecular machinery. When studying these molecules we have to make sense of a diverse set of dynamical nanostructures with wast and intricate patterns of interactions. READ MORE

  5. 5. The Swedish Version of the Philadelphia Geriatric Center Multilevel Assessment Instrument (PGCMAI) Development and testing in an old-age population with locomotor disability

    University dissertation from Institutionen för medicin och hälsa

    Author : Margareta Minhage; Elisabeth Hamrin; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gender; locomotor disability; PGCMAI; old age; reliability; validity; INTERDISCIPLINARY RESEARCH AREAS Caring sciences Nursing; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN Vårdvetenskap Omvårdnad;

    Abstract : The general aim was to examine the Swedish version of the Philadelphia Geriatric Center Multilevel Assessment Instrument, PGCMAI, in a population of old people with locomotor disability in Sweden. Specific aims were to examine whether the Swedish version of the PGCMAI meets the criteria of reliability and validity when assessing the life situation of Swedish old people with locomotor disability and to explore the pattern of the Swedish version of the instrument in respect of age and gender. READ MORE