Search for dissertations about: "Funktionsgenomik"
Showing result 16 - 20 of 64 swedish dissertations containing the word Funktionsgenomik.
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16. Activation, reaction mechanism and allosteric regulation of the anaerobic ribonucleotide reductase from bacteriophage T4
Abstract : Ribonucleotide reductase (RNR) catalyse the conversion of ribonucleotides to their corresponding deoxyribonucleotides in all organisms. The deoxyribonucleotides are the building blocks for DNA. Three different classes of RNR are found, class I, II and III. READ MORE
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17. Development of benzoquinoquinoxaline derivatives as triplex-specific probes : Recognition of DNA structures at repeats sequences
Abstract : Repeat sequences are associated with several human diseases, such as Friedreich’s ataxia, polycystic kidney disease and cancer. These sequences can form non-B-DNA structures, including triplex (H-DNA) DNA, and are associated with genomic instability and altered gene expression. READ MORE
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18. The Path to Destruction : Understanding the mechanism and regulation of proteasomal degradation
Abstract : A majority of intracellular proteins are degraded by the ubiquitin proteasome system (UPS). In this thesis, both the mechanism of the degradation and the regulation of UPS have been investigated. The importance of the p97 ATPase for proteasomal degradation of cytosolic substrates was examined. READ MORE
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19. Chromosome synapsis and recombination in yeast meiosis
Abstract : Meiosis is a cell division process that produces haploid gametes from diploid cells. Several important meiotic events take place during prophase of meiosis I, most important being homologous chromosome pairing, meiotic recombination and formation of the synaptonemal complex (SC). READ MORE
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20. Genetic and molecular dissection of hemolymph coagulation and melanization in Drosophila melanogaster
Abstract : Injury to epithelial barriers puts metazoans at risk of loss of body fluid and contamination of their body by foreign particles. This risk is even exacerbated in insects, which have an open circulatory system and as a result, quickly need to seal wounds in order to keep a fairly constant internal milieu. READ MORE