Search for dissertations about: "Fusion Genes"

Showing result 1 - 5 of 144 swedish dissertations containing the words Fusion Genes.

  2. 1. Human Forkhead Genes

    Author : Stefan Pierrou; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; transcription factor; FREAC; human forkhead homologues;

    Abstract : The forkhead family constitutes a group of genes which encodes transcription factors that share a common DNA-binding domain, the forkhead domain. The first member to be discovered was the Drosophila melanogaster gene fork head. Members of this family have been found in a variety of species from bakers' yeast to man. READ MORE

  4. 2. EWSR1 and FUS fusion genes in tumorigenesis

    Author : Emely Möller; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The present thesis concerns the involvement of EWSR1 and FUS fusion genes, and the chimeric proteins they encode, in tumorigenesis. In Article I, the EWSR1 promoter, which regulates the expression of EWSR1 fusion genes, was characterized and regions that were crucial for promoter activity could be identified. READ MORE

  5. 3. Studies of Cellular Regulatory Mechanisms : from Genetic Switches to Cell Migration

    Author : Maria Werner; Erik Aurell; Ulrich Gerland; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plasma physics; Plasmafysik;

    Abstract : Cellular behaviour depends ultimately on the transcription of genes. If we know how transcription is controlled we have a better chance of understanding cellular processes. This thesis presents six studies, all concerning cellular regulatory mechanisms. One study is purely experimental and five are computational studies. READ MORE

  6. 4. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects

    Author : Gunnar Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ewing s sarcoma; synovial sarcoma; translocation; fusion gene; fusion protein; diagnosis and prognosis;

    Abstract : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. READ MORE

  7. 5. Genetic dissection of tubulogenesis in the Drosophila trachea

    Author : Johanna Hemphälä; Christos Samakovlis; Reinhard Schuh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; trachea; transposon mutagenesis screen; fusion; Dpp; Delta; tubular dimensions; Grainyhead; Krotzkopf verkehrt; intralumenal matrix; Developmental biology; Utvecklingsbiologi;

    Abstract : The formation of branched tubular organs, such as the mammalian lung kidney and vascular system, is an essential process in animal development. The Drosophila tracheal (respiratory) system provides a genetic model system to study the highly ordered process of branch outgrowth and fusion required to form continuous tubular networks. READ MORE