Search for dissertations about: "Göran Alderborn"

Showing result 6 - 10 of 17 swedish dissertations containing the words Göran Alderborn.

2. 6. Studies on the importance and characterization of particle fragmentation during tabletting

   Author : Göran Alderborn; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Abstract : .... READ MORE

4. 7. Engineering of Pharmaceutical Particles : Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process

   Author : Jonas Berggren; Göran Alderborn; Graham Buckton; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; particle engineering; microcrystalline cellulose pellets; intragranular porosity; convective drying; tabletting behaviour; spray-dried composite particles; amorphous lactose; PVP; heat and moisture-induced crystallisation; glass transition temperature; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

   Abstract : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. READ MORE

5. 8. Spray-Dried Powders for Inhalation : Particle Formation and Formulation Concepts

   Author : Jessica Elversson; Göran Alderborn; Anna Millqvist-Fureby; Lars Hovgaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Spray drying; Particle formation; Density; Protein formulation; Encapsulation; Coating; Competitive adsorption; Polymer; ESCA; AFM; FTIR; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : Spray drying is a method with a high potential in the preparation of protein particles suitable for pulmonary delivery. However, surface induced denaturation of bio-molecules during atomization and subsequent drying can be substantial and it is therefore important to develop new formulation concept for concurrent encapsulation and stabilization of proteins during spray drying. READ MORE

6. 9. Identification and Variation of some Functionality Related Characteristics of Pharmaceutically Relevant Solid Materials and their Effect on Product Performance

   Author : Frauke Fichtner; Göran Alderborn; Åke Rasmuson; Peter Kleinebudde; Uppsala universitet; []
   Keywords : Pharmaceutics; Particle size distribution; Degree of agglomeration; Amorphous lactose; Matrix agglomerates; Drug release; Compactability; Tablet tensile strength; Particle fracture strength; Surfactant; Compression; Galenisk farmaci;

   Abstract : The aim of this thesis was to identify some functionality related characteristics of pharmaceutically relevant solid materials and to study the effect of their variation on processing behaviour and product performance. For this purpose, particles with different characteristics were prepared under a variety of conditions by crystal agglomeration, wet granulation and spray drying. READ MORE

7. 10. On the chemical and processing stability of pharmaceutical solids : Solid form dependent water presenting capacity and process induced solid form transformation

   Author : Mina Heidarian Höckerfelt; Göran Alderborn; Stefan Ulvenlund; Uppsala universitet; []
   Keywords : ;

   Abstract : There is a need for improving our knowledge and understanding about formation mechanisms and nature of amorphous state in order to prevent the unintended presence of disorder in solid pharmaceutical products and reduce the related stability issues. The suggested theory that water binding capacity of amorphous cellulose affects the chemical stability of hydrolysis sensitive drugs in formulations with cellulose based excipients needs a clarification and water-cellulose interaction profiles need to be examined. READ MORE