Search for dissertations about: "G protein-coupled receptor"
Showing result 6 - 10 of 168 swedish dissertations containing the words G protein-coupled receptor.
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6. Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils
Abstract : The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl peptide receptors (FPRs) and the short free fatty acid receptors (FFARs) belong to the family of G protein coupled receptors (GPCR). READ MORE
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7. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators
Abstract : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. READ MORE
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8. Electrophysiology-based investigations of G protein-coupled receptor pharmacology
Abstract : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. READ MORE
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9. New approaches to data-driven analysis and enhanced sampling simulations of G protein-coupled receptors
Abstract : Proteins are large biomolecules that carry out specific functions within living organisms. Understanding how proteins function is a massive scientific challenge with a wide area of applications. In particular, by controlling protein function we may develop therapies for many diseases. READ MORE
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10. The Gene Repertoire of G protein-coupled Receptors : New Genes, Phylogeny, and Evolution
Abstract : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. READ MORE