Search for dissertations about: "G-alpha-i2"

Found 1 swedish dissertation containing the word G-alpha-i2.

2. 1. Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis

   Author : Yu-Yuan Chiu Götlind; Göteborgs universitet; []
   Keywords : IBD; G-alpha-i2 colitis; Tregs; Teffs; Th17 Th1; pathogenesis immunoregulation;

   Abstract : The two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC) are gastrointestinal disorders characterized by chronic and relapsing inflammation. Mice deficient in the inhibitory G protein subunit Gαi2 spontaneously develop chronic colitis and have been used as a model for IBD, with particular similarities to UC. READ MORE