Search for dissertations about: "G3BP"

Found 4 swedish dissertations containing the word G3BP.

  2. 1. Regulation of cellular growth and identification of stromal gene signatures in breast cancer

    Author : Sofia Winslow; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; cellular stress; proliferation; PKCα; G3BP; PMP22; miR-34c; gene expression profiles; stroma;

    Abstract : Normal tissue is tightly controlled to keep a balance between reproduction and elimination of cells. In cancer, these regulated processes are disrupted, resulting in uncontrolled cell growth. Regulation of RNA stability and turnover is important to maintain cellular homeostasis and can be controlled by various mechanisms. READ MORE

  4. 2. Alphavirus-host interactions : how to unravel the proviral activity of G3BP

    Author : Benjamin Götte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The genus Alphavirus belongs to the virus family Togaviridiae, a group of arthropod-borne enveloped RNA viruses with single-stranded, positive-sense genome. Members of this genus can be found worldwide and are geographically distinguished into Old World and New World alphaviruses. READ MORE

  5. 3. Dissection of virus-host cell interactions in the early response to infection

    Author : Marc D Panas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Stress granules (SG) are dynamic RNA/protein assemblies in the cytoplasm of the cell, formed under conditions of oxidative stress, heat shock or viral infections. These stress conditions trigger a sudden translational arrest, leading to a rapid switch of translation from housekeeping genes to stress-related factors. READ MORE

  6. 4. Exploration of host cells during old world alphavirus infection : modulation of RNA granules and the PI3K/AKT pathway

    Author : Lifeng Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : As obligate intracellular parasites, viruses have to explore and modulate cellular pathways for their survival. Mechanistic studies of virus–host interactions provide a better understanding of viral infection and cellular responses and help to identify potential targets for therapeutic intervention. READ MORE