Search for dissertations about: "GABA B receptor"

Showing result 6 - 10 of 11 swedish dissertations containing the words GABA B receptor.

2. 6. Applying the Pump and Leak Hypothesis. An experimental and theoretical investigation of the principles of ion regulation and excitability in the crustacean stretch receptor neuron

   Author : Sten Theander; Människan i rörelse: hälsa och rehabilitering; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; lobster; stretch receptor neuron; leak current; Q-current; K-Cl cotransporter; A-current; mathematical model; excitability; GABA channel; neurophysiology; ion regulation; neuropsykologi; Neurologi; neurofysiologi;

   Abstract : An invertebrate nerve cell preparation, the lobster stretch receptor neuron, was investigated with respect to maintenance of its resting voltage, intracellular ion concentrations and excitability using voltage clamp technique and ion-selective microelectrodes. It was found that the resting voltage (-65 mV) of microelectrode impaled cells is caused by (a) a homogenous population of K+ channels which we denoted as leak channels (b) an electrogenic and voltage-dependent Na-K pump current and (c) an inward microelectrode-induced "impalement" current carried mainly by Na+. READ MORE

4. 7. Glutamate and GABA signalling components in the human brain and in immune cells

   Author : Amol K. Bhandage; Bryndis Birnir; Gerard P. Ahern; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuroscience; Neurovetenskap; Immunologi; Immunology;

   Abstract : Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous system (CNS). They both can activate their ionotropic and metabotropic receptors. READ MORE

5. 8. On amino acid neurotransmitters in the spinal cord motor nuclei

   Author : Göran Örnung; Karolinska Institutet; Karolinska Institutet; []
   Keywords : neurotransmitter; aspartate; glutamate; GABA. glycine; homocysteate; taurine; ultrastructure; freeze-substitution; immunocytochemistry; bouton; synaptic input; motoneuron; strech reflex; spinal cord; cat. rat;

   Abstract : Using pre- and post-embedding immunocytochemistry, the distribution of six amino acid neurotransmitter candidates, with special reference to y-amino-butyric acid (GABA), glycine and glutamate was examined in boutons apposing somata and dendrites in the lumbar motor nuclei of the cat spinal cord. The monosynaptic connection between muscle spindle I a afferents and motoneurons regarding content of neuroactive amino acid and complement of amino acid receptors in the postsynaptic membrane was studied in the rat. READ MORE

6. 9. Characterization of neuropeptide, monoamine, and amino acid release in the basal ganglia of the rat : neuronal dependence and reciprocal interactions

   Author : Zhi-Bing You; Karolinska Institutet; Karolinska Institutet; []
   Keywords : amino acids cholecystokinin dopamine dynorphin microdialysis morphineneostriatum rat substantia nigra.;

   Abstract : Functional interactions in the basal ganglia of rats were characterized with in vivomicrodialysis. The study was mainly focused on the dynorphin and cholecystokinin (CCK) systems. The extracellular levels of both dynorphin B and CCK were found in the pM range inthe neostriatum and substantia nigra under basal conditions. READ MORE

7. 10. The hippocampal opioid system : role in spatial learning

   Author : Johan Sandin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : opioid; dynorphin; nociceptin; hippocampus; learning; memory; acetylcholine; HPLC; microinjections;

   Abstract : The main aim of the present thesis was to study the role of the endogenous hippocampal opioid system, and in particular, the role of dynorphin B and nociceptin, in spatial learning. The effects of bilateral infusion (using chronic cannulae) of dynorphin B into the dorsal hippocampus (CA3-region), an area containing a high number of dynorphin-containing neurons, were examined in the Morris swim-maze, a spatial task dependent on hippocampal functioning. READ MORE