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Showing result 1 - 5 of 13 swedish dissertations matching the above criteria.

  2. 1. Ethanol-induced modulation of dopamine transmission and synaptic activity in striatal subregions - focus on inhibitory receptors

    Author : Rhona B. C. Clarke; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; ethanol; acetaldehyde; striatum; glycine receptor; GABA A receptor;

    Abstract : Background: Alcoholism is a chronic brain disease, affecting neurocircuitries involved in reward and learning. The rewarding effects of alcohol (ethanol) are believed to result from increased dopamine levels in the nucleus accumbens (nAc) via the mesolimbic system. READ MORE

  4. 2. GABA signaling regulation by GLP-1 receptor agonists and GABA-A receptors modulator

    Author : Omar M. Babateen; Bryndis Birnir; Lena Eliasson; Uppsala universitet; []
    Keywords : Neuroscience; Neurovetenskap;

    Abstract : GABA (γ-aminobutyric acid) is the main neuroinhibitory transmitter in mammalian brains.  It binds to GABA-A and GABA-B receptors. The GABA-A receptors are ligand-gated chloride channels. A variety of GABA-A receptor agonists and antagonists have been developed to study the GABA-mediated inhibition and to explore new medications. READ MORE

  5. 3. GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome

    Author : Helena Hedström; Torbjörn Bäckström; Marie Bixo; Ian Milsom; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; isoallopregnanolone; gonadotropins; GABA-A receptor; women; polycystic ovary syndrome; saccade; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: The progesterone metabolite allopregnanolone is involved in several clinical conditions in women, e.g. premenstrual dysphoric disorder. It is a very potent GABA-steroid with GABA-A receptor effects similar to other GABA-agonists, e. READ MORE

  6. 4. Tolerance and antagonism to allopregnanolone effects in the rat CNS

    Author : Sahruh Turkmen; Inga-Maj Johansson; Agneta Nordberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABA-A receptor; UC1011; Spatial memory; Morris Water Maze; Tolerance; Silent second; mRNA; Obstetrics and gynaecology; Obstetrik och gynekologi;

    Abstract : Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive steroids. READ MORE

  7. 5. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels

    Author : Yuxuan Zhuang; Erik Lindahl; Grace Brannigan; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channels; molecular dynamics; markov state model; lipid modulation; nicotinic receptor; protein conformational transitions; Biophysics; biofysik;

    Abstract : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. READ MORE