Search for dissertations about: "GBF1"

Found 4 swedish dissertations containing the word GBF1.

  2. 1. Viperin vs. tick-borne encephalitis virus : mechanism of a potent antiviral protein

    Author : Kirstin Vonderstein; Anna Överby Wernstedt; Magnus Evander; Sonja Best; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Abstract : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. READ MORE

  4. 2. Regulation of chloroplast development during the greening process

    Author : Yan Ji; Åsa Strand; Eevi Rintamäki; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Arabidopsis thaliana; light response; anterograde signalling; plastid transcription; chloroplast development; photosynthesis; bZIP; PEP complex; de-etiolation; molekylärbiologi; Molecular Biology;

    Abstract : Upon light exposure, the expression of one-third of the nuclear-encoded genes is changing, including genes encoding many chloroplast-targeted proteins responsible for the initiation of plastid transcription and the establishment of photosynthesis. The control of the nuclear-encoded genes involved in the development of chloroplast is referred to as anterograde signalling. READ MORE

  5. 3. Tissue Microarrays for Analysis of Expression Patterns

    Author : Cecilia Lindskog Bergström; Fredrik Pontén; Anna Asplund; Ari Ristimäki; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue microarrays; Antibody-based proteomics; Immunohistochemistry; Biomarker discovery; Diabetes; Lung cancer; Influenza virus; Evolution; Pathology; Patologi;

    Abstract : Proteins are essential building blocks in every living cell, and since the complete human genome was sequenced in 2004, researchers have attempted to map the human proteome, which is the functional representation of the genome. One such initiative is the Human Protein Atlas programme (HPA), which generates monospecific antibodies towards all human proteins and uses these for high-throughput tissue profiling on tissue microarrays (TMAs). READ MORE

  6. 4. Viperin, a multifunctional radical SAM enzyme : biogenesis and antiviral mechanisms

    Author : Arunkumar Upadhyay; Anna K. Överby; Niklas Arnberg; Richard Lundmark; Michael Beard; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. READ MORE