Search for dissertations about: "GHR"

Showing result 1 - 5 of 20 swedish dissertations containing the word GHR.

2. 1. Growth hormone and somatolactin function during sexual maturation of female Atlantic salmon

   Author : Susana Benedet Perea; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Growth hormone; somatolactin; insulin-like growth factor I; GH; SL; IGFI; GHR; SLR; IGFIR; ovary maturation; reproduction; Atlantic salmon; spawning; pituitary;

   Abstract : Background and aims: The growth hormone-insulin-like growth factor I (GH-IGF-I) system is known to act during sexual maturation of female salmonids, but the specific roles are not known. Somatolactin (SL) is a pituitary hormone closely related to GH and is only found in fish. In some species, including salmonids, there are two forms, SLa and SLß. READ MORE

4. 2. The growth hormone receptor and growth hormone sensitivity in man

   Author : Ruth Wickelgren; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GH sensitivity; GH receptor; quantitative RT-PCR; IGF-I; skeletal muscle; adipose tissue; tissue-specific; promoter; 5´-untranslated region; psoriasis; epidermis;

   Abstract : It is well established that the response to endogenous and exogenous growth hormone (GH) varies between individuals. For example, conditions with increased catabolic rate, such as trauma, sepsis and surgery, are believed to be associated with acquired GH insensitivity. READ MORE

5. 3. Negative regulation of growth hormone (GH) signaling

   Author : Elizabeth Rico Bautista; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Growth Hormone (GH) regulates postnatal longitudinal growth. It also has several other functions. It decreases cholesterol and lipoproteins levels, reduces fat tissue and increases lean body mass. GH actions are mediated by the JAK2/STAT5 signaling pathway. READ MORE

6. 4. Prolactin and growth hormone in breast cancer. Studies of human breast cancer and transgenic tumor models

   Author : Maria Gebre-Medhin; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prolactin; growth hormone; breast cancer; transgenic mice; estrogen receptor; insulin-like growth factor; insulin-like growth factor-I receptor;

   Abstract : Prolactin (PRL) and growth hormone (GH) are two related pituitary peptide hormones of importance during normal mammary gland development. Furthermore, their involvement in development and growth of malignant mammary tumors has been suggested by several investigators. READ MORE

7. 5. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes

   Author : Martin Ridderstråle; Diabetes - klinisk obesitasforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin receptor substrate-1; insulin receptor substrate-2 phosphatidylinositol 3-kinase; signal transducer and activator of transcription 5; janus kinase 2; phosphotyrosine; receptor; phosphorylation; Growth hormone; Metabolism; Biochemistry; rat; adipocyte; lipolysis; lipogenesis; Biokemi; metabolism; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Abstract : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. READ MORE