Search for dissertations about: "GIRK"

Found 3 swedish dissertations containing the word GIRK.

  2. 1. A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory

    Author : Fredrik Johansson; Associativ inlärning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebellum; Purkinje cell; Timing; Temporal; Memory; Eyeblink conditioning; mGluR7; Kir3; GIRK;

    Abstract : The standard view of neural signaling is that a neuron can influence its target cell by exciting or inhibiting it. Learning is thought to involve strengthening or weakening synaptic connections. For most behaviors, the brain must learn to produce precisely timed activity patterns. READ MORE

  4. 2. Electrophysiology-based investigations of G protein-coupled receptor pharmacology

    Author : Richard Ågren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. READ MORE

  5. 3. Voltage sensitivity of dopamine D2-like receptors

    Author : Kristoffer Sahlholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands. READ MORE