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Showing result 1 - 5 of 86 swedish dissertations matching the above criteria.

  2. 1. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

    Author : Linda Ahlkvist; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

    Abstract : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. READ MORE

  4. 2. IL-6 and GLP-1 in body fat regulating parts of the CNS in healthy mice

    Author : Fredrik Anesten; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6Rα; GLP-1; obesity; hypothalamus; brainstem; tanycytes; immunohistochemistry;

    Abstract : It has previously been shown that mice lacking interleukin-6 (IL-6) develop mature onset obesity. The weight-suppressing effects of IL-6 have been assumed to be exerted at a central level, as supported by the fact that ICV- injections, but not peripheral injections of IL-6, increases energy expenditure and decreases body fat in rodents. READ MORE

  5. 3. Impaired Glucose Tolerance in Childhood Obesity : Contribution of Glucagon, GLP-1 and Inflammation

    Author : Hannes Manell; Peter Bergsten; Anders Forslund; Jens Juul Holst; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood obesity; impaired glucose tolerance; type 2 diabetes; glucagon; glucagon-like peptide-1; dipeptidyl peptidase-4; inflammation; free fatty acids; insulin; visceral adiposity; Medicinsk vetenskap; Medical Science;

    Abstract : In the wake of increased obesity prevalence, impaired glucose tolerance (IGT) and type 2 diabetes (T2D) in childhood and adolescence is increasingly common. Given the negative impacts these conditions have on health over time, understanding the pathophysiology in those affected early in life is important. READ MORE

  6. 4. Role of GLP-1 receptor agonists in endothelial function

    Author : Özlem Erdogdu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Type 2 diabetes;

    Abstract : BACKGROUND: The leading cause of death for patients suffering from type 2 diabetes is macrovascular disease. Endothelial dysfunction is one of the earliest events identified in the pathogenesis of atherosclerosis. Hence, there is a need for finding glucose-lowering agents that cause direct positive effects on vasculature in diabetic patients. READ MORE

  7. 5. Save the brain! Studies on GLP-1-mediated neuroprotection

    Author : Martin Larsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Patients with type 2 diabetes (T2D) suffer stroke more often and have worse recovery. Moreover, hyperglycemic stroke patients treated with thrombolytic therapy have more intracranial bleedings. READ MORE