Search for dissertations about: "GLP-1"

Showing result 21 - 25 of 86 swedish dissertations containing the word GLP-1.

  2. 21. Strategies to improve outcome after islet transplantation using the GLP-1 receptor agonist, extendin-4

    Author : Amit Sharma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Transplantation of pancreatic islets into the liver via the portal vein has emerged as a treatment option for patients with type I diabetes mellitus. However, loss of functional beta cell mass during isolation and following implantation is a major obstacle in obtaining good long-term results. READ MORE

  4. 22. Development of nuclear medicine methods for gastric and small bowel motility : effects of GLP-1 on gastric emptying

    Author : Per Grybäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Gastric emptying; ghrelin; glucagon-like peptide-1; 99mTc-HIDA; obesity; radionuclide investigation; small bowel transit.;

    Abstract : The diagnosis of functional disorders of the gastrointestinal (GI) tract requires techniques being both sufficiently sensitive to detect disturbances of the normal physiology and low-invasive enough not to interfere with the properties being studied. The purpose was to set up nuclear medicine methods for assessment of upper GI tract motility and study the effect of glucagon-like peptide-1 (GLP-1) on gastric emptying. READ MORE

  5. 23. Metabolic and endocrine effects of SGLT2 inhibition

    Author : Per Lundkvist; Jan Eriksson; Lars Lind; Maria J Pereira; Michael Alvarsson; Uppsala universitet; []
    Keywords : SGLT2 inhibition; GLP-1 receptor agonism; DPP4 inhibition; NAFLD; prediabetes; type 2 diabetes; obesity; metabolic syndrome; glucagon.; Medicinsk vetenskap; Medical Science;

    Abstract : Obesity and type 2 diabetes (T2D) are two growing global health problems with similar comorbidity profiles. SGLT2 inhibitors (SGLT2i) improve blood glucose control and can relieve both T2D and obesity, as well as their associated health problems such as hypertension, kidney failure, and cardiovascular disease. READ MORE

  6. 24. GLP-1 secretion and signaling in patients with aneurysmal enlargement of the thoracic aorta : a potential contributor to reduced prevalence of aneurysm in diabetes

    Author : Stelia Ntika; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : An aortic aneurysm is a localized dilation of the artery, greater than 50% of the normal size. It is the result of a weakening of the aortic wall, and untreated or unrecognized aortic aneurysms may be fatal due to massive internal bleeding, as a result of dissection or rupture of the aneurysm. READ MORE

  7. 25. Glucagon Counter-Regulation to Hypoglycemia During Incretin-Based Therapy

    Author : Johan Farngren; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Incretin; DPP-4; GLP-1; Glucagon; Hypoglycemia; Diabetes;

    Abstract : Incretin-based therapy is associated with low risk of hypoglycemia in type 2 diabetes mellitus (T2DM) possibly due to its glucose-dependency in stimulating insulin secretion and a sustained glucagon response during hypoglycemia. This is of special relevance when it is combined with insulin or given to elderly patients since both insulin therapy and high age are associated with impaired glucagon counter-regulation. READ MORE