Search for dissertations about: "GLUT4"

Showing result 1 - 5 of 33 swedish dissertations containing the word GLUT4.

  1. 1. Glucose and lipid metabolism in insulin resistance an experimental study in fat cells

    University dissertation from Umeå : Folkhälsa och klinisk medicin

    Author : Jonas Burén; Umeå universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; MEDICINE Social medicine Public health medicine research areas; MEDICIN Socialmedicin Folkhälsomedicinska forskningsområden; medicin; Medicine;

    Abstract : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. READ MORE

  2. 2. Regulation of glucose transport and insulin-stimulated GLUT4 translocation in skeletal muscle

    University dissertation from Stockholm : Karolinska Institutet, Department of Surgical Science

    Author : Jorge E. Rincón Viatela; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; skeletal muscle; glucose transport; insulin resistance; hyperglycaemia; steroid hormones; smoking; nicotine;

    Abstract : Skeletal muscle represents about 40% of body mass and accounts for at least 80% of glucose disposal under insulin-stimulated conditions. Furthermore, GLUT4 transport protein is the primary component of the glucose transport system in skeletal muscle. READ MORE

  3. 3. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise

    University dissertation from Stockholm : Karolinska Institutet, Department of Surgical Science

    Author : Jeffrey W. Ryder; Karolinska Institutet.; Karolinska Institutet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; skeletal muscle; glucose transport; GLUT4; hypoxia; exercise; Type II diabetes; MAPK; PPAR[gamma] thiazolidinediones;

    Abstract : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. READ MORE

  4. 4. Gene regulation, intracellular signaling and membrane traffic : Studies in primary human skeletal muscle cultures

    University dissertation from Stockholm : Karolinska Institutet, Department of Surgical Science

    Author : Lubna Al-Khalili; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

    Abstract : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. READ MORE

  5. 5. Insulin and growth hormone: regulation of adipocyte metabolism during infancy and childhood

    University dissertation from Stockholm : Karolinska Institutet, -

    Author : Ashraf Fawzy Kamel; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; rat; development; adipocytes; lipolysis; lipogenesis; glucose transport GLUT1; GLUT4; insulin; insulin receptor; growth hormone; growth hormone receptor microdialysis; obesity; Prader-Willi syndrome;

    Abstract : The aim of the present investigation was to investigate the role of insulin and growth (GH) in adipose tissue metabolism during development. Lipolysis and lipogenesis were studied in isolated adipocytes from humans and rats of various ages. READ MORE