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Showing result 1 - 5 of 35 swedish dissertations matching the above criteria.

  2. 1. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells

    Author : Jonas Burén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; medicin; Medicine;

    Abstract : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. READ MORE

  4. 2. Targeting Nutrient Transporters in Acute Myeloid Leukemia

    Author : Hannah Åbacka; Medicinsk strukturbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Akut myeloisk leukemi; Metabolism; Transportörer; GLUT1; GLUT4; CD36; AQP7; ASPL; Inhibitor; Glukos; Fettsyra; Glycerol; Acute myeloid leukemia; Metabolism; Transporter; GLUT1; GLUT4; CD36; AQP7; ASPL; Small-molecule inhibitor; Glucose; Fatty acid; Glycerol;

    Abstract : .... READ MORE

  5. 3. Regulation of glucose transport and insulin-stimulated GLUT4 translocation in skeletal muscle

    Author : Jorge E Rincón Viatela; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; glucose transport; insulin resistance; hyperglycaemia; steroid hormones; smoking; nicotine;

    Abstract : Skeletal muscle represents about 40% of body mass and accounts for at least 80% of glucose disposal under insulin-stimulated conditions. Furthermore, GLUT4 transport protein is the primary component of the glucose transport system in skeletal muscle. READ MORE

  6. 4. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise

    Author : Jeffrey W Ryder; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; glucose transport; GLUT4; hypoxia; exercise; Type II diabetes; MAPK; PPAR[gamma] thiazolidinediones;

    Abstract : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. READ MORE

  7. 5. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures

    Author : Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

    Abstract : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. READ MORE