Search for dissertations about: "GPCR Activation Mechanism"

Showing result 1 - 5 of 15 swedish dissertations containing the words GPCR Activation Mechanism.

  2. 1. The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

    Author : Ulrika Mårtensson; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; HIV SIV; TIG2 chemerin; transcriptional regulation; ligand activation; Co-receptor; GPCR; ChemR23 CMKLR1;

    Abstract : In all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. READ MORE

  4. 2. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Author : Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. READ MORE

  5. 3. New approaches to data-driven analysis and enhanced sampling simulations of G protein-coupled receptors

    Author : Oliver Fleetwood; Lucie Delemotte; Erik Lindahl; Ulrich Zachariae; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; GPCR; G protein-coupled receptors; Molecular Dynamics; MD; Enhanced Sampling; beta2 adrenergic receptor; beta2; Biological Physics; Biologisk fysik;

    Abstract : Proteins are large biomolecules that carry out specific functions within living organisms. Understanding how proteins function is a massive scientific challenge with a wide area of applications. In particular, by controlling protein function we may develop therapies for many diseases. READ MORE

  6. 4. Chemoattractant receptor signaling and neutrophil acctivation. Involvement of the cytoskeleton

    Author : Huamei Fu; Göteborgs universitet; []
    Keywords : neutrophils; G-protein coupled receptors; signaling; cytoskeleton;

    Abstract : Neutrophil granulocytes play a vital role in the host surveillance system and form the first line of defense against microbial infections. The migration of neutrophils to an infected/inflamed tissue is guided by chemoattractants released either from intruding microbes or from activated/damaged host cells. READ MORE

  7. 5. Modulation of Receptor Signaling and Functional Selectivity in Neutrophils

    Author : Michael Gabl; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; G-protein coupled receptors; reactive oxygen species; ligands; functional selectivity; allosteric modulation;

    Abstract : Neutrophils are important effector cells of the innate immune system and in the regulation of inflammation. Many of their functions, such as chemotactic migration, secretion of granule constituents and activation of the oxygen radical-producing NADPH-oxidase, are regulated by cell surface receptors. READ MORE