Search for dissertations about: "GPG motif"

Found 3 swedish dissertations containing the words GPG motif.

  2. 1. Effect of the tri-peptide glycyl-prolyl-glycine amide on HIV-1 replication

    Author : Jin Su; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; antiretrovirals; peptides; tri-peptides; GPG-NH2; capsid formation; p24 dimerization; coneshaped core; GPG motif; V3 loop; infectivity;

    Abstract : The human immunodeficiency virus type 1 (HIV-1) is the etiological agent responsible for AIDS worldwide. The aim of this thesis was to evaluate the anti-HIV-1 activity of short peptides and to investigate their mode of inhibition. READ MORE

  4. 2. Genotypic and serotypic characterization of HIV in Ethiopia

    Author : Kimdar Sherefa Kemal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; V3; serotype; genotype; recombination;

    Abstract : The human immunodeficiency virus type I (HIV-1) is characterized by a high genomic heterogeneity. Different subtypes and inter-subtype recombinants have been identified in the HIV pandemic. The most precise and widely used method for subtype classification is based on molecular biology techniques; nucleotide sequencing of partial genomic fragments. READ MORE

  5. 3. Studies on HIV-1 core assembly

    Author : Samir Abdurahman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; mutation; capsid; p24; capsid assembly; alpha-HGA; antiviral;

    Abstract : The main objective of this thesis was to define the roles of Gag (p55), in particular, the capsid (CA, p24) protein in human immunodeficiency virus type 1 (HIV-1) particle assembly. More specifically, i) to determine the relative contribution of some specific residues and/or sequences in HIV-1 CA core assembly and virus release, ii) to characterize the importance of two conserved residues with quite opposing intra-molecular contacts with other CA residues in capsid assembly, iii) to define the role and significance of a specific amino acid involved in formation of a conserved β-hairpin structure in HIV-1 capsid assembly, and iv) to define the active antiviral metabolite of an antiviral tripeptide amide previously found to affect HIV-1 capsid assembly and infectivity. READ MORE