Search for dissertations about: "GPIbalpha"
Found 1 swedish dissertation containing the word GPIbalpha.
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1. Role of GPIbαlpha Clustering and N-linked Carbohydrates in the Clearance of Refrigerated Platelets
Abstract : The thesis focuses on understanding the mechanisms by which: 1) the macrophage alphaM-subunit recognizes betaN-acetylglucosamine (betaGlcNAc) residues on the von Willebrand factor receptor complex ((GPIbalpha,beta/IX)2V or vWfR) on refrigerated platelets and 2) refrigeration changes vWfR to elicit recognition through alphaMbeta2. Until recently, the only well-established mechanisms affecting platelet survival were antibody-mediated platelet clearance, consumption of platelets by coagulation reactions, and loss due to massive bleeding. READ MORE