Search for dissertations about: "GRN"
Showing result 1 - 5 of 12 swedish dissertations containing the word GRN.
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1. Towards Reliable Gene Regulatory Network Inference
Abstract : Phenotypic traits are now known to stem from the interplay between genetic variables across many if not every level of biology. The field of gene regulatory network (GRN) inference is concerned with understanding the regulatory interactions between genes in a cell, in order to build a model that captures the behaviour of the system. READ MORE
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2. The role of leptin in zebrafish (Danio rerio) : Novel insights into appetite regulation and reproduction
Abstract : The hormone leptin is a peripheral metabolic signal and an important regulator of energy balance. In mammals, leptin acts on the appetite centers in the hypothalamus, causing anorexigenic functions by inhibiting food intake. It is also considered as a link between the nutritional status and the endocrine reproductive axis. READ MORE
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3. Exploring the Boundaries of Gene Regulatory Network Inference
Abstract : To understand how the components of a complex system like the biological cell interact and regulate each other, we need to collect data for how the components respond to system perturbations. Such data can then be used to solve the inverse problem of inferring a network that describes how the pieces influence each other. READ MORE
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4. Genetic characterization of patients with frontotemporal dementia and amyotrophic lateral sclerosis in the Nordic countries
Abstract : Frontotemporal dementia (FTD) is the second most common form of neurodegenerative disease affecting people under the age of 65 years. The general symptoms are dysfunctions in behavior and/or language. READ MORE
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5. In silico modelling for refining gene regulatory network inference
Abstract : Gene regulation is at the centre of all cellular functions, regulating the cell's healthy and pathological responses. The interconnected system of regulatory interactions is known as the gene regulatory network (GRN), where genes influence each other to maintain strict and robust control. READ MORE