Search for dissertations about: "GRP94"

Showing result 1 - 5 of 6 swedish dissertations containing the word GRP94.

  2. 1. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans

    Author : Balasubramanian Natarajan; Peter Naredi; Richard Padgett; Umeå universitet; []
    Keywords : Insulin; C. elegans; ASNA1; Cisplatin; GRP94; unfolded protein response; SMN1; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. READ MORE

  4. 2. A UDP-glucose deficient mutant cell line as a model to study the cytotoxicity of Clostridium perfringens PLC

    Author : Marietta Flores Diaz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A Chinese Hamster fibroblast mutant cell line, deficient in UDP-glucose (UDP-Glc) and hypersensitive to Clostridium perfringens phospholipase C (PLC) was used in this study to determine some of the molecular consequences of a cellular UDP-Glc deficiency. Furthermore, using this cell as a model, structure/function studies were performed to identify residues critical for the cytotoxic activity of PLC. READ MORE

  5. 3. Oral mucosa keratinocytes and their exosomes for epithelial tissue regeneration

    Author : Sebastian Sjöqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Early tumors, including high grade dysplasia and intramucosal invasive cancer, of the esophagus can today be removed using endoscopic resection, often using a technique called endoscopic submucosal dissection (ESD). This treatment is better tolerated and has considerably less mortality and morbidity compared to conventional, more invasive surgery, which usually entails esophagectomy. READ MORE

  6. 4. Molecular consequences of cellular UDP-glucose deficiency

    Author : Juan Carlos Higuita V; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A Chinese hamster fibroblast mutant cell line, deficient in UDP-glucose (UDPG), denoted as Qc, and its counterpart cell line with normalized levels of UDPG (G3), were used to determine some molecular consequences of chronic UDPG deficiency. The UDPG deficient cells lacked glycogen, had elevated rates of glucose uptake and a decreased capacity to synthesize glycogen after 120h of culture. READ MORE

  7. 5. Characterization of ERp29 : a novel secretion factor of endoplasmic reticulum

    Author : Ernest Sargsyan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : ERp29 is a ubiquitously expressed endoplasmic reticulum protein strongly conserved in mammalian species. The N-terminal domain of ERp29 is similar to the thioredoxin domain of protein disulfide isomerase (PDI) lacking however the double-cysteine active site motif. The C-terminal domain is a novel five-helical fold. READ MORE