Search for dissertations about: "GSTM1"
Showing result 6 - 10 of 19 swedish dissertations containing the word GSTM1.
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6. Significance of polymorphisms in human xenobiotic metabolising enzymes
Abstract : Cigarette smoke is the primary cause of lung cancer but urban air pollution and certain occupational exposures have also been found to elevate the incidence of lung cancer. These exposures contain polycyclic aromatic hydrocarbons (PAH), which can be metabolically activated to highly reactive compounds capable of binding to DNA and initiating the carcinogenic process unless they are eliminated. READ MORE
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7. Genetic polymorphism of human drug metabolising enzymes : structural and functional studies
Abstract : There is a pronounced interindividual variability in the levels and activity of many drug metabolising enzymes, which might cause differences in the sensitivity to and the toxicity of many clinically used drugs as well as environmental compounds such as nicotine and precarcinogens. In the present investigation the molecular genetic basis for some of the differences in the CYP2A6, CYP2D6, CYP2E1 and GSTM1 enzymes have been elucidated. READ MORE
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8. Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers
Abstract : Workers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. READ MORE
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9. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor
Abstract : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. READ MORE
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10. Carcinogenic polycyclic aromatic hydrocarbons : role of human glutathione transferases in conjugate formation and DNA protection
Abstract : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which requires metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bay- and fjord region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. READ MORE