Search for dissertations about: "GVL"

Showing result 1 - 5 of 11 swedish dissertations containing the word GVL.

2. 1. Leukaemic relapse after allogeneic haematopoietic stem cell transplantation and the use of the graft-versus-leukaemia effect

   Author : Stefan Carlens; Karolinska Institutet; Karolinska Institutet; []
   Keywords : haematopoietic stem cell transplantation; GVHD; GVL; DLI; T-cell culture; retroviral transduction; NK-cell culture;

   Abstract : Survival after allogeneic haematopoietic stem cell transplantation (HSCT) has improved over the last decades due to improvements in immunosuppressive regimens and supportive care. Today the major risk of treatment failure is recurrent leukaemia, a risk which has stayed relatively constant over the years. READ MORE

4. 2. Immune repertoire diversity in allogeneic stem cell transplantation and its implications for infections and the graft versus leukemia effect

   Author : Andreas Björklund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The beneficial graft versus leukemia effect (GVL) and its detrimental counterparts, graft versus host disease (GVHD) and susceptibility to infections, are all coupled to a multitude of events during the immune reconstitution (IR) after hematopoietic stem cell transplantation (HSCT). The general aim of this thesis has been to learn more about the IR in HSCT with a particular focus on the impact of infections, natural killer (NK) cell mediated GVL effects and the possibility to apply GVL effects in adoptive cell therapy. READ MORE

5. 3. Effects on tumor immunity, liver, gut, lung and survival after cutaneous graft-versus-host disease regulated by photochemotherapy

   Author : Gustav Nicolas Feldreich; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The present thesis describes the effect and timing of photochemotherapy in relation to the onset and severity of cutaneous graft-versus-host (GvHD) in relation to the survival and cure of patients. Leukemia is the most common childhood malignancy and an entity of cancer that is increasing in elderly. READ MORE

6. 4. Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect

   Author : Alexandra Treschow; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Gene therapy; cell selection; suicide gene; cancer; immunotherapy; viral vectors; thymidine kinase; Na ; K -ATPase;

   Abstract : For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to be developed. Transplant-related morbidity and mortality are severe complications arising from this treatment modality. READ MORE

7. 5. The methodology and significance of minimal residual disease detection after allogeneic stem cell transplantation

   Author : Mehmet Uzunel; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Minimal Residual Disease; Stem Cell Transplantation; ALL; AML; CML; Relapse;

   Abstract : Allogeneic stem cell transplantation (SCT) is the choice of therapy for leukemia patients who respond poorly to conventional chemotherapy. Despite high remission rates after SCT, relapse of the underlying disease remains one of the most frequent causes of treatment failure. READ MORE