Search for dissertations about: "GWAS"
Showing result 21 - 25 of 108 swedish dissertations containing the word GWAS.
-
21. Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies
Abstract : Recently, the pace of growth in the amount of data sources within Life Sciences has increased exponentially until pose a difficult problem to efficiently manage their integration. The data avalanche we are experiencing may be significant for a turning point in science, with a change of orientation from proprietary to publicly available data and a concomitant acceptance of studies based on the latter. READ MORE
-
22. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes
Abstract : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. READ MORE
-
23. Translational genetics identifies a novel target to treat fatty liver disease
Abstract : Fatty liver disease (FLD) is rapidly prevailing as the most common liver disease worldwide, with an estimated of one-quarter of the global population affected. Environmental and genetic determinants contribute to FLD susceptibility. READ MORE
-
24. Conservation genomics in inbred Scandinavian wolves using bioinformatic methods
Abstract : With the recent and unprecedented progress in retrieving DNA sequence information from a large number of individuals of any species, conservation genetic research has entered a new phase. Specifically, it has become possible to study how genomes of endangered species respond to reductions in population size. READ MORE
-
25. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
Abstract : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. READ MORE