Search for dissertations about: "Gai2- - mice"

Found 2 swedish dissertations containing the words Gai2- - mice.

  2. 1. Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis

    Author : Maria Fritsch Fredin; Göteborgs universitet; []
    Keywords : colitis; Gai2- - mice; dextran sodium sulfate; ex vivo cultures; micro-Computed Tomography; IEL; thymus; Inflammatory Bowel Disease;

    Abstract : The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. The second aim was to investigate new ways of assessing and monitoring colitis. READ MORE

  4. 2. Immunopathogenesis of Gai2-deficient mice. A model of inflammatory bowel disease

    Author : Lena Öhman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammatory Bowel Disease; Mucosa; Apoptosis; Bordetella pertussis; G-protein;

    Abstract : The intestinal mucosa is the largest lymphoid organ in the body, and it simultaneously has to protect us from any pathogen that might enter the gastrointestinal tract as well as maintaining tolerance to most antigens, mainly in the form of dietary constituents and microbial products. A dysfunctional control of local intestinal immune responses may lead to development of Inflammatory Bowel Disease (IBD) - the common name for ulcerative colitis (UC) and Crohn´s disease (CD). READ MORE