Search for dissertations about: "GalT-KO pig"

Found 1 swedish dissertation containing the words GalT-KO pig.

2. 1. Biochemical studies of carbohydrate blood group antigens - Carbohydrate phenotype in relation to cellular glycosyltranferases

   Author : Mette Diswall; Göteborgs universitet; []
   Keywords : glycosphingolipid; glycosyltransferase; genetic modification; carbohydrate; mass spectrometry; proton NMR spectroscopy; xenotransplantation; GalT-KO pig;

   Abstract : The possibility to alter the cell surface carbohydrate expression by insertion or deletion of glycosyltransferase genes is a powerful technique to study the biological function of selected carbohydrate antigens. However, shifting the equilibrium between competing glycosyltransferases might lead to unexpected phenotypic effects, such as accumulation of other carbohydrate antigens and exposure of antigen structures that normally are cryptic or present in minute amounts on the cell surface. READ MORE