Search for dissertations about: "Gamma-tubulin"
Showing result 1 - 5 of 7 swedish dissertations containing the word Gamma-tubulin.
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1. The gamma-tubulin meshwork as a therapeutic target
Abstract : Cancer is a heterogeneous disease and treatment regime is dependent on type and location of the tumor. Several of the commonly used chemotherapeutics target the functions of the microtubules. One of the major problems with these drugs is the adverse effects associated with their use. READ MORE
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2. The role of gamma-tubulin in cell division and cancer
Abstract : Although cancer is a heterogeneous disease, a common theme in tumor cells is the deregulation of cell division, which renders tumor progression independent of otherwise necessary internal or external growth cues. This may provide cancer cells with the ability to divide indefinitely, posing a threat to the rest of the organism. READ MORE
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3. Characterization of the inner nuclear membrane protein Samp1, during interphase and mitosis
Abstract : The nucleus, a hallmark in eukaryotic cells, contains the genome separating it from molecules in the cytoplasm. The nucleus is surrounded by a nuclear envelope consisting of two concentric membranes, the outer nuclear membrane and the inner nuclear membrane, the nuclear lamina and nuclear pore complexes. READ MORE
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4. Tumor Suppressor function of the deubiquitinating enzyme BAP1 and its substrate gamma-tubulin In regulation of cell cycle and genome stability
Abstract : In normal cells, the cell cycle is controlled by a complex series of signalling pathways by which a cell grows, replicates its DNA and divides. The critical task of the cell cycle is to ensure that DNA is faithfully replicated and that identical chromosomal copies are distributed equally to two daughter cells during mitosis with the help of the mitotic spindle. READ MORE
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5. Differential expression pattern of CEACAM1 isoforms in polarized epithelial cells : it's regulation and some functional consequences
Abstract : The cell adhesion molecule CEACAM1 is expressed in epithelia, small vessel endothelia and leukocytes as two major, co-expressed isoforms, CEACAM1-L and CEACAM1-S, which differ in their cytoplasmic domains. CEACAM1 has been found both in cell-cell contact areas and on apical surfaces of polarized epithelial cells. READ MORE