Search for dissertations about: "Gangliosides synthesis"
Found 5 swedish dissertations containing the words Gangliosides synthesis.
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1. The involvement of gangliosides in growth and migration of human glioblastoma cells
Abstract : Human glioblastoma is a primary brain tumour with a bad prognosis. One major contributing factor is that the tumour grows in an infiltrative way. Single tumour cells, undetectable with today's techniques, invade the brain and escape therapy. READ MORE
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2. Synthesis of Conformationally Restricted Oligosaccharides
Abstract : Gangliosides are sialic acid-containing glycosphingolipids that often are present in increased amounts on tumor cells. Since the gangliosides are hydroxy-acids, they can form lactones. The lactones have been suspected to be more immunogenic than the open forms, but are in practise poor immunogens due to their ease of hydrolysis. READ MORE
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3. Synthetic analogs of sialyl Lewis x
Abstract : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. READ MORE
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4. Some New Methods in Sialic Acid Chemistry
Abstract : Gangliosides (G) are sialic acid-containing cell surface glycosphingolipids capable of forming lactones, i.e. inner esters. Some gangliosides are tumor-associated antigens, and they may serve as immunogens in their lactone form, where the latter is comparatively more abundant on the surface of malignant cells. READ MORE
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5. A UDP-glucose deficient mutant cell line as a model to study the cytotoxicity of Clostridium perfringens PLC
Abstract : A Chinese Hamster fibroblast mutant cell line, deficient in UDP-glucose (UDP-Glc) and hypersensitive to Clostridium perfringens phospholipase C (PLC) was used in this study to determine some of the molecular consequences of a cellular UDP-Glc deficiency. Furthermore, using this cell as a model, structure/function studies were performed to identify residues critical for the cytotoxic activity of PLC. READ MORE