Search for dissertations about: "Gangliosides synthesis"

Found 5 swedish dissertations containing the words Gangliosides synthesis.

  1. 1. Synthesis of Conformationally Restricted Oligosaccharides

    University dissertation from Organic Chemistry, Lund University

    Author : Michael Wilstermann; Lunds universitet.; Lund University.; [1997]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Streptococcus suis; E. coli; neoglycolipid; ganglioside-lactam; xylose; methylene acetal; sialic acid; Conformational Restriction; galabiose; Organic chemistry; Organisk kemi;

    Abstract : Gangliosides are sialic acid-containing glycosphingolipids that often are present in increased amounts on tumor cells. Since the gangliosides are hydroxy-acids, they can form lactones. The lactones have been suspected to be more immunogenic than the open forms, but are in practise poor immunogens due to their ease of hydrolysis. READ MORE

  2. 2. Synthetic analogs of sialyl Lewis x

    University dissertation from Organic Chemistry, Lund University

    Author : Ulf Ellervik; Lunds universitet.; Lund University.; [1998]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; stereoselective synthesis; regioselective synthesis; lactam analogs; lactone; Selectin; Sialyl Lewis x; SLex; Organic chemistry; Organisk kemi;

    Abstract : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. READ MORE

  3. 3. The involvement of gangliosides in growth and migration of human glioblastoma cells

    University dissertation from Organic Chemistry, Lund University

    Author : Kristina Hedberg; Göteborgs universitet.; Gothenburg University.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gangliosides synthesis; Ganglioside expression; Glioblastoma; Migration; Proliferation; Cell culture systems; Xenograft model;

    Abstract : Human glioblastoma is a primary brain tumour with a bad prognosis. One major contributing factor is that the tumour grows in an infiltrative way. Single tumour cells, undetectable with today's techniques, invade the brain and escape therapy. READ MORE

  4. 4. Some New Methods in Sialic Acid Chemistry

    University dissertation from Organic Chemistry, Lund University

    Author : Teddy Ercegovic; Lunds universitet.; Lund University.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; thioglycoside promoter; ganglioside; Tumor-associated antigen; lactam; lactone; sialic acid; N-acetylneuraminic acid; Neu5Ac; sialyl donor; auxiliary group; 3- S -phenylthio; bis-sialic acid lactam; 3- S -phenylseleno; silver trifluoromethanesulfonate; iodine monochloride; Organic chemistry; Organisk kemi;

    Abstract : Gangliosides (G) are sialic acid-containing cell surface glycosphingolipids capable of forming lactones, i.e. inner esters. Some gangliosides are tumor-associated antigens, and they may serve as immunogens in their lactone form, where the latter is comparatively more abundant on the surface of malignant cells. READ MORE

  5. 5. A UDP-glucose deficient mutant cell line as a model to study the cytotoxicity of Clostridium perfringens PLC

    University dissertation from Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Author : Marietta Flores Diaz; Karolinska Institutet.; Karolinska Institutet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : A Chinese Hamster fibroblast mutant cell line, deficient in UDP-glucose (UDP-Glc) and hypersensitive to Clostridium perfringens phospholipase C (PLC) was used in this study to determine some of the molecular consequences of a cellular UDP-Glc deficiency. Furthermore, using this cell as a model, structure/function studies were performed to identify residues critical for the cytotoxic activity of PLC. READ MORE