Search for dissertations about: "Gas6"

Showing result 1 - 5 of 6 swedish dissertations containing the word Gas6.

  2. 1. Structural and Functional Studies of Gas6

    Author : Jonas Stenhoff; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; EDTA; calcium; multimer; monomer; platelets; Mer; Axl; vitamin K; Gas6; human circulation; soluble receptor; Tyro3; receptor tyrosine kinases; growth factor;

    Abstract : The vitamin K-dependent and ubiquitously expressed 82 kDa glycoprotein product of the growth-arrest-specific-gene 6, Gas6, shows 44% sequence identity to the anticoagulant protein, protein S. Both proteins share further the same domain organization. READ MORE

  4. 2. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S

    Author : Petra Evenäs; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; tyrosine phosphorylation.; Sky receptor; SHBG-like region; protein S; G domain; Gas6; Activated protein C; C4b-binding protein; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. READ MORE

  5. 3. The Soluble Form of the Axl Receptor Tyrosine Kinase

    Author : Carl Ekman; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The present investigation focus on the receptor Axl, which is a member of the receptor tyrosine kinase family. Axl is activated by the ligand Gas6 inducing cell growth and proliferation, but also regulate inflammation and vascular homeostasis. READ MORE

  6. 4. A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma

    Author : Anna Gustafsson; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The present investigation is a multifaceted study of the receptor tyrosine kinase Axl, whose overexpression and activation is implicated in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 (Tns3). READ MORE

  7. 5. Axl RTK and microRNAs in urogenital cancers

    Author : Helena Fritz; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. READ MORE